Evidence map›Paper›PMID 37063904›Full record

Observational studyFrontiers in immunology2023

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation.

Kristina Rydenfelt, Gisle Kjøsen, Rune Horneland, Judith Krey Ludviksen, Trond Geir Jenssen, Pål-Dag Line, Tor Inge Tønnessen, Tom Eirik Mollnes, Håkon Haugaa, Søren Erik Pischke

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01957696 (A Prospective, Observational Study in Pancreatic Allograft Recipients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01957696 enrolling by invitationnot on this map

A Prospective, Observational Study in Pancreatic Allograft Recipients: The Effect of Risk Factors, Immunosuppressive Level and the Benefits of Scheduled Biopsies - on Surgical Complications, Rejections and Graft Survival

Typeobservational_patient_registrySponsorOslo University HospitalRan2013 to 2028Enrolled80ConditionsDiabetes Mellitus, Pancreas Transplantation, Allograft Rejection, Surgical Complication Nec
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kristina RydenfeltDepartment of Anesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Gisle KjøsenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rune HornelandDepartment of Transplantation Medicine, Section of Transplantation Surgery, Oslo University Hospital, Oslo, Norway.
Judith Krey LudviksenResearch Laboratory, Nordland Hospital, Bodø, Norway.
Trond Geir JenssenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Pål-Dag LineInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Tor Inge TønnessenDepartment of Anesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Tom Eirik MollnesResearch Laboratory, Nordland Hospital, Bodø, Norway.
Håkon HaugaaDepartment of Anesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Søren Erik PischkeDepartment of Anesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NONordland Hospital · NOUniversity of Oslo · NOLovisenberg Diakonale Høgskole · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pancreas transplant alone (PTA) recipients are more affected by pancreas graft thrombosis, and graft loss compared to simultaneous pancreas-kidney (SPK) recipients. The pathophysiology is unknown, but an increased immune response has been suggested in the PTA recipients. In this observational study, we compared perioperative thromboinflammation between PTA (n=32) and SPK (n=35) recipients, and between PTA recipients with (n=14) versus without (n=18) early graft thrombosis. Methods: We measured C-reactive protein (CRP), plasma markers of activated coagulation and complement, and cytokines preoperatively and daily during the first postoperative week. Results: Preoperatively, coagulation and complement activation markers were comparable between PTA and SPK recipients, while cytokine concentrations were higher in SPK recipients (TNF, IL-8, IP-10, MCP-1, MIP-1α; all Conclusion: The relative increase in postoperative thromboinflammatory response was more pronounced in PTA recipients. Complement activation was associated with an increased risk of graft thrombosis. This study indicates that innate immune activation rather than elevated levels may affect early postoperative pancreas graft thrombosis. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT01957696, identifier NCT01957696.

Indexed as

Kidney TransplantationPancreas TransplantationThrombosisChemokine CCL3Chemokine CXCL10Complement ActivationHumansInflammationInterleukin-8PancreasChemokine CCL3Chemokine CXCL10Interleukin-8coagulationcomplementcytokinespancreas graft thrombosispancreas transplant alonesimultaneous pancreas-kidney transplantationthromboinflammation

Identifiers

PMID37063904
PMCPMC10090504
OpenAlexW4361296083

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.