Evidence map›Paper›PMID 37063781›Full record

ArticleNeurology. Clinical practice2023

Antiseizure Medication Withdrawal Practice Patterns: A Survey Among Members of the American Academy of Neurology and EpiCARE.

Samuel W Terman, Geertruida Slinger, Carol E Rheaume, Anisa S Haque, Shawna N Smith, Renate van Griethuysen, Charlotte J J van Asch, Willem M Otte, James F Burke, Kees P J Braun

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In one paragraph

Article in Neurology. Clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Samuel W TermanDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Geertruida SlingerDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Carol E RheaumeDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Anisa S HaqueDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Shawna N SmithDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Renate van GriethuysenDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Charlotte J J van AschDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Willem M OtteDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
James F BurkeDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).
Kees P J BraunDepartment of Neurology (SWT), University of Michigan, Ann Arbor; Department of Child Neurology (GS, WMO, KB), UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, the Netherlands; American Academy of Neurology (CER), Minneapolis, MN; University of Michigan Medical School (ASH); Department of Health Management and Policy (SNS), School of Public Health, University of Michigan, Ann Arbor; Department of Clinical Neurophysiology and Sleep Centre SEIN Zwolle (RvG, CJJvA), the Netherlands; Department of Neurology (JFB), the Ohio State University, Columbus; and Member of the European Reference Network EpiCARE (KPJB).ORCID https://orcid.org/0000-0003-3631-0003
European Union · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: To describe neurologist practice patterns, challenges, and decision support needs pertaining to withdrawal of antiseizure medications (ASMs) in patients with well-controlled epilepsy. Methods: We sent an electronic survey to (1) US and (2) European physician members of the American Academy of Neurology and (3) members of EpiCARE, a European Reference Network for rare and complex epilepsies. Analyses included frequencies and percentages, and we showed distributions through histograms and violin plots. Results: We sent the survey to 4,923 individuals; 463 consented, 411 passed eligibility questions, and 287 responded to at least 1 of these questions. Most respondents indicated that they might ever consider ASM withdrawal, with respondents treating mostly children being more likely ever to consider withdrawal (e.g., medical monotherapy: children 96% vs adults 81%; Discussion: Most surveyed neurologists would consider withdrawing ASMs in seizure-free individuals. Seizure probability was the largest factor driving decisions, yet estimating seizure probabilities was the greatest challenge. Respondents on average indicated that they may withdraw ASM after a minimum seizure-free duration of 2 years, yet also on average were willing to withdraw when seizure risk decreased below 15%-30%, which is lower than most patients' postwithdrawal risk at 2-year seizure freedom and lower than the equivalent even of a first seizure of life. These findings will inform future efforts at developing decision support tools aimed at optimizing ASM withdrawal decisions.

Identifiers

PMID37063781
PMCPMC10101711
OpenAlexW4317392716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.