Evidence map›Paper›PMID 37063755›Full record

ReviewResearch and practice in thrombosis and haemostasis2023

Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management.

Syed Mahamad, Dimpy Modi, Hanny Al-Samkari, Adam Cuker, Jenny M Despotovic, Joseph E Italiano, Michele P Lambert, Eun-Ju Lee, Matthew T Rondina, Michelle Sholzberg and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Research and practice in thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Management of Adult Primary Immune Thrombocytopenia: Delphi-Based Consensus RecommendationsTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 2 countries.

Syed MahamadDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Dimpy ModiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Hanny Al-SamkariDivision of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Adam CukerDepartment of Medicine and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jenny M DespotovicDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.
Joseph E ItalianoDepartment of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
Michele P LambertDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Eun-Ju LeeHematology/Oncology Department, Weill Cornell Medical College, New York, New York, USA.
Matthew T RondinaDepartment of Internal Medicine & The Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.
Michelle SholzbergDepartment of Medicine, and Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario, Canada.
Caroline KrusePlatelet Disorder Support Association, Cleveland, Ohio, USA.
Mark LarchéDivision of Clinical Immunology & Allergy, and Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Ishac NazyDivision of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Matthew S MillerDepartment of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Donald M ArnoldDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CAUniversity of Pennsylvania · USBaylor College of Medicine · USBoston Children's Hospital · USCornell University · USMassachusetts General Hospital · USMcMaster University Medical Centre · CASt. Michael's Hospital · CASunnybrook Health Science Centre · CAUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inaugural McMaster Immune Thrombocytopenia (ITP) Summit was held virually in 2021. The objectives of the Summit were to recognize the difficulties in establishing the diagnosis of ITP and to understand gaps in current knowledge of ITP mechanisms that might lead to better diagnostic approaches and treatments. The half-day program consisted of virtual educational sessions targeting clinicians and basic scientists. The planning committee chose 8 topics to review that would cover current knowledge and inform future research priorities. In this report, we summarized the presentations delivered at the 2021 McMaster ITP Summit and the discussions. Based on the information presented at the Summit, the following research priorities were identified: 1) investigation of platelet production as a target for ITP treatments; 2) characterization of antigen processing and antigen presentation on platelets; 3) interaction between megakaryocytes and the immune system; 4) the role for ITP gene panels; 5) the need for better methods for platelet antibody testing; 6) the role of prediction models for diagnosis and prognosis; 7) new treatment strategies, including intensification of initial therapy; and 8) personalized treatment algorithms.

Indexed as

bleedingimmune thrombocytopeniaimmunologymegakaryocytesplatelet

Identifiers

PMID37063755
PMCPMC10099320
OpenAlexW4322491975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.