Evidence map›Paper›PMID 37063754›Full record

ArticleResearch and practice in thrombosis and haemostasis2023

Acquired blood platelet disorder in patients with end-stage heart failure after implantation of a continuous centrifugal-flow left ventricular assist device: A prospective cohort study.

Omayra C D Liesdek, Roger E G Schutgens, Linda M de Heer, Faiz Z Ramjankhan, Silvie A E Sebastian, Joline J Rohof, Willem J L Suyker, Rolf T Urbanus

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06510322 (Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06510322 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support

TypeinterventionalSponsorMontefiore Medical CenterRan2025 to 2029Enrolled50ConditionsVascular DiseasesArmsSildenafil, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Key markers and detection methods for evaluating platelet dysfunction in mechanical circulatory support devices.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Omayra C D LiesdekDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Roger E G SchutgensCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, the Netherlands.
Linda M de HeerDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Faiz Z RamjankhanDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Silvie A E SebastianCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, the Netherlands.
Joline J RohofCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, the Netherlands.
Willem J L SuykerDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Rolf T UrbanusCenter for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, the Netherlands.
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Continuous-flow left ventricular assist devices (CF-LVADs) are an established therapy for advanced heart failure. Thrombosis and hemorrhage are common complications after CF-LVAD implantation, which may be explained by device-induced platelet activation. Few data on the effect of CF-LVAD implantation on platelets are available to date. Objectives: The aim of this study was to characterize the change in the platelet activation status after CF-LVAD. Methods: Platelet phenotype and reactivity were determined with flow cytometry in 32 adults with end-stage heart failure before and 4 to 6 weeks after CF-LVAD implantation. Sixteen adults with a biological aortic valve prosthesis (AVP) using the same antiplatelet regimen were included to discriminate between the effects of CF-LVAD and the antiplatelet regimen. Plasma markers for platelet activation were determined with enzyme-linked immunosorbent assay. Results: Median (IQR) plasma levels of soluble P-selectin increased from 115.6 (79.1-142.7) ng/mL to 144.5 (100.4-197.5) ng/mL after CF-LVAD implantation ( Conclusions: Combined, these data provide evidence for systemic platelet activation and an acquired platelet disorder after CF-LVAD implantation. This might contribute to the risk of both hemorrhage and thrombosis associated with CF-LVADs.

Indexed as

blood platelet disorderhemorrhageplatelet activationthrombosisventricular assist device

Identifiers

PMID37063754
PMCPMC10099325
OpenAlexW4323321827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.