Evidence map›Paper›PMID 37063750›Full record

ArticlePulmonary circulation2023

Novel left ventricular mechanical index in pulmonary arterial hypertension.

Kenzo Ichimura, Everton J Santana, Tatiana Kuznetsova, Nicholas Cauwenberghs, František Sabovčik, Lindsey Chun, Nadia L C Francisco, Vitaly O Kheyfets, Michael Salerno, Roham T Zamanian and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Kenzo IchimuraDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Stanford University Stanford California USA.ORCID 0000-0002-5734-335X
Everton J SantanaDepartment of Medicine, Division of Cardiovascular Medicine Stanford University Stanford California USA.ORCID 0000-0002-6014-9857
Tatiana KuznetsovaResearch Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences University of Leuven Leuven Belgium.
Nicholas CauwenberghsResearch Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences University of Leuven Leuven Belgium.
František SabovčikResearch Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences University of Leuven Leuven Belgium.
Lindsey ChunCardiovascular Institute Stanford University Stanford California USA.
Nadia L C FranciscoCardiovascular Institute Stanford University Stanford California USA.
Vitaly O KheyfetsPediatric Critical Care Medicine; Developmental Lung Biology and CVP Research Laboratories, School of Medicine University of Colorado Aurora Colorado USA.
Michael SalernoDepartment of Medicine, Division of Cardiovascular Medicine Stanford University Stanford California USA.
Roham T ZamanianDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Stanford University Stanford California USA.
Edda SpiekerkoetterDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Stanford University Stanford California USA.
Francois HaddadVera Moulton Wall Center of Pulmonary Vascular Disease Stanford School of Medicine Stanford California USA.
Cardiovascular Institute of the South · USKU Leuven · BEHealth First · USStanford Medicine · USStanford University · USUniversity of Colorado Denver · US

Funding

Targeting Novel BMPR2 modifiers in Pulmonary Hypertension with Repurposed DrugsR01HL128734 · NHLBI · STANFORD UNIVERSITY · PI SPIEKERKOETTER, EDDA FRAUKE · 2016 to 2020
$2.1M
What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?R01HL152250 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Vitaly Kheyfets · 2023 to 2026
$1.9M
Understanding and targeting molecular as well as structural events governing right ventricular adaptation, failure and recovery in pulmonary hypertension using repurposed drugsR01HL158868 · NHLBI · STANFORD UNIVERSITY · PI SPIEKERKOETTER, EDDA FRAUKE · 2021 to 2024
$1.7M
Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertensionK25HL133481 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KHEYFETS, VITALY · 2017 to 2021
$605k
Cause and effect of transient changes in stress, gene expression, and RV fiber orientation during RV remodeling, and its impact on RV function and inter-ventricular coupling in pulmonary hypertensionR56HL152250 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KHEYFETS, VITALY · 2021 to 2021
$404k
NHLBI NIH HHS K25 HL133481NHLBI NIH HHS R01 HL128734NHLBI NIH HHS R01 HL152250NHLBI NIH HHS R01 HL158868NHLBI NIH HHS R56 HL152250
6 · The paper itself

Abstract

Ventricular interdependence plays an important role in pulmonary arterial hypertension (PAH). It can decrease left ventricular (LV) longitudinal strain (LVLS) and lead to a leftward displacement ("transverse shortening") of the interventricular septum (sTS). For this study, we hypothesized the ratio of LVLS/sTS would be a sensitive marker of systolic ventricular interactions in PAH. In a cross-sectional cohort of patients with PAH (

Indexed as

echocardiographypulmonary hypertensionventricular function

Identifiers

PMID37063750
PMCPMC10103585
OpenAlexW4362464757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.