ArticleAnnals of occupational and environmental medicine2023
The association of perfluoroalkyl substances (PFAS) exposure and kidney function in Korean adolescents using data from Korean National Environmental Health Survey (KoNEHS) cycle 4 (2018-2020): a cross-sectional study.
Article in Annals of occupational and environmental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 19 citations in OpenAlex.
- PFAS exposure in 12-year-old children and its association with metabolic markers.Pediatric research · 2026Article
- Association of F-53B Nephrotoxicity with Oxidative Stress-Mediated Mitochondrial Dysfunction and Altered Autophagy-Apoptosis Crosstalk.Biomolecules · 2026Article
- Long-Term Per- and Polyfluoroalkyl Substances Exposure and Kidney Function in Taiwanese Adolescents and Young Adults: A 10-Year Prospective Cohort Study.Journal of xenobiotics · 2026Article
- Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status.Ecotoxicology and environmental safety · 2025Article
- Reference values of per- and poly- fluoroalkyl substances concentration in serum and related factors in Korean adults: Korean National Environmental Health Survey.Environmental analysis, health and toxicology · 2025Article
- Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes.Scientific reports · 2025Article
- Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review.Ewha medical journal · 2025Review
- Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease.International journal of environmental research and public health · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing concerns. In particular, effects on kidney function have recently emerged and there are no studies on the effect of PFAS on kidney function through epidemiological investigations in Korea. From 2018 to 2020, the Korean National Environmental Health Survey (KoNEHS) cycle 4, conducted an epidemiological investigation on the blood concentration of PFAS for the first time in Korea. Based on this data, the relationship between PFAS blood concentration and kidney function was analyzed for adolescents. Methods: We investigated 5 types of PFAS and their total blood concentration in 811 middle and high school students, living in Korea and included in KoNEHS cycle 4, and tried to find changes in kidney function in relation to PFAS concentration. After dividing the concentration of each of the 5 PFAS and the total concentration into quartiles, multivariable linear regression was performed to assess the correlation with kidney function. The bedside Schwartz equation was used as an indicator of kidney function. Results: As a result of multivariable linear regression, when observing a change in kidney function according to the increase in the concentration of each of the 5 PFAS and their total, a significant decrease in kidney function was confirmed in some or all quartiles. Conclusions: In this cross-sectional study of Korean adolescents based on KoNEHS data, a negative correlation between serum PFAS concentration and kidney function was found. A well-designed longitudinal study and continuous follow-up are necessary.
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