ReviewFrontiers in neural circuits2023
From pupil to the brain: New insights for studying cortical plasticity through pupillometry.
Review in Frontiers in neural circuits, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of caffeine intake on pupillary parameters in humans: a systematic review and meta-analysis.Behavioral and brain functions : BBF · 2024Pooled it
- Protocol of the randomized double blind sham controlled AddVNS study of transcutaneous vagus nerve stimulation mechanisms in depression.Scientific reports · 2026Trial
- Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Clinical Validation of Pupil Response During Walking in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Spontaneous perceptual reversals are accompanied by systematic changes in pupil size but not respiration phase.Scientific reports · 2026Article
- Oculometric Function More Strongly Predicts Working Memory than Stress in Military Officers.Journal of eye movement research · 2026Article
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- No significant modulation of pressure pain sensitivity and cardioception after transauricular vagal nerve stimulation.Pain reports · 2026Article
- Mental fatigue in football: methodology and experimental protocol.Frontiers in sports and active living · 2026Article
- Article
- Dimensionality reduction techniques in pupillometry research: A primer for behavioral scientists.Behavior research methods · 2025Article
- Challenges in using pupil dilation responses to sounds as a reliable alternative to standard audiometric tests.Heliyon · 2025Article
- Pre-AttentiveGaze: gaze-based authentication dataset with momentary visual interactions.Scientific data · 2025Article
- Article
- External trigeminal nerve stimulation for neuropsychiatric disorders: mechanisms, efficacy, and future directions.Frontiers in neurology · 2025Review
- Task-specific cortical mechanisms of taVNS-paired task-oriented training for post-stroke upper extremity dysfunction under cognitive load: an fNIRS study.Frontiers in human neuroscience · 2025Article
- Evidence of physiological changes associated with single-session pre-frontal tDCS: a pilot study.Frontiers in human neuroscience · 2025Article
- Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry.Advances in neurobiology · 2025Review
- Eye pupils mirror information divergence in approximate inference.Scientific reports · 2024Article
- Automated ultrasonographic pupillary assessment: a new neuro-ophthalmological assessment tool.The Journal of international medical research · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pupil size variations have been associated with changes in brain activity patterns related with specific cognitive factors, such as arousal, attention, and mental effort. The locus coeruleus (LC), a key hub in the noradrenergic system of the brain, is considered to be a key regulator of cognitive control on pupil size, with changes in pupil diameter corresponding to the release of norepinephrine (NE). Advances in eye-tracking technology and open-source software have facilitated accurate pupil size measurement in various experimental settings, leading to increased interest in using pupillometry to track the nervous system activation state and as a potential biomarker for brain disorders. This review explores pupillometry as a non-invasive and fully translational tool for studying cortical plasticity starting from recent literature suggesting that pupillometry could be a promising technique for estimating the degree of residual plasticity in human subjects. Given that NE is known to be a critical mediator of cortical plasticity and arousal, the review includes data revealing the importance of the LC-NE system in modulating brain plasticity and pupil size. Finally, we will review data suggesting that pupillometry could provide a quantitative and complementary measure of cortical plasticity also in pre-clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.