Evidence map›Paper›PMID 37063324›Full record

ReviewFrontiers in nutrition2023

Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis.

Kristina Hoffman, William J Doyle, Sean M Schumacher, Javier Ochoa-Repáraz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  5. Impact of a GABA-ProducingFASEB bioAdvances · 2026
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  7. Review
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kristina HoffmanDepartment of Biological Sciences, Boise State University, Boise, ID, United States.
William J DoyleDepartment of Biological Sciences, Boise State University, Boise, ID, United States.
Sean M SchumacherDepartment of Biological Sciences, Boise State University, Boise, ID, United States.
Javier Ochoa-RepárazDepartment of Biological Sciences, Boise State University, Boise, ID, United States.
Boise State University · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
PAR04-122, Extramural Research Facilities Construction:*C06RR020533 · NCRR · BOISE STATE UNIVERSITY · PI RUDIN, MARK JOSEPH · 2010 to 2010
$4.0M
Targeting the GABA-modulator microbiota against the progression of CNS inflammatory demyelinationR15NS107743 · NINDS · EASTERN WASHINGTON UNIVERSITY · PI OCHOA-REPARAZ, JAVIER, ROULLET, JEAN-BAPTISTE O · 2019 to 2019
$419k
NCRR NIH HHS C06 RR020533NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NINDS NIH HHS R15 NS107743
6 · The paper itself

Abstract

Over the last few decades, the incidence of multiple sclerosis has increased as society's dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the "Western diet." Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the "Western diet" as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease.

Indexed as

dietdietary factorsdietary interventionsEAEgut dysbiosisgut microbiomemultiple sclerosis

Identifiers

PMID37063324
PMCPMC10090556
OpenAlexW4361299086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.