ArticleCancer2023
Influence of depression on breast cancer treatment and survival: A Kentucky population-based study.
Article in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Diagnostic Prediction Models for Depression in Patients With Breast Cancer: A Systematic Review.Journal of clinical nursing · 2026Pooled it
- Bilateral transcutaneous auricular vagus nerve stimulation for the treatment of insomnia in breast cancer.Scientific reports · 2025Trial
- Development of Psychosocial Distress in Cancer Survivors and Its Potential Prognostic Impact on Survival: A Scoping Review.Psycho-oncology · 2026Article
- Impact of Pre-Diagnosed Depressive Symptoms on Treatment Choice, Delay in Initiating Treatment, and Mortality Among Women Aged ≥65 Years with Breast Cancer.International journal of environmental research and public health · 2026Article
- [Assessment of patient-reported outcomes as an instrument for patient-centered care?]Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- Analysis the incidence and related risk factors of depression in patients with esophageal cancer combined with bone metastasis.World journal of psychiatry · 2026Article
- Depression and cancer outcomes in resource-limited settings: A cross-sectional analysis of treatment uptake and survival among metastatic breast cancer patients in Lagos, Nigeria.PLOS global public health · 2026Article
- Residential Fast-Food Exposures, Colorectal Cancer-Specific, and All-Cause Mortality: A Retrospective Study of CRC Cases from the Kentucky Cancer Registry.Nutrition and cancer · 2026Article
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Depression, anxiety, and stress in breast cancer patients: prevalence, associated risk factors, and clinical correlates.Scientific reports · 2025Article
- Stage at diagnosis and breast cancer-specific mortality in breast cancer patients treated with antidepressants, anxiolytics, and antipsychotics: a population-based cohort study from Northern Ireland.Breast cancer research and treatment · 2025Article
- Early identification and prevention of depressive symptoms in breast cancer patients.World journal of clinical oncology · 2025Article
- Molecular mechanisms and clinical value of the correlation between depression and cancer.Medical oncology (Northwood, London, England) · 2025Review
- Changes in health behaviors and risk of depression after breast cancer diagnosis and treatment: a nationwide cohort study.Journal of cancer survivorship : research and practice · 2025Article
- Association between the Chinese Dietary Balance Index-based dietary quality and depressive symptoms in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Psychometric Properties of the Depression Anxiety Stress Scales (DASS-42 and DASS-21) in Patients with Hematologic Malignancies.Journal of clinical medicine · 2025Article
- Evaluation of psychological status in early-stage breast cancer outpatients: a cross-sectional study utilizing the Kessler 10 Scale.BMC psychiatry · 2025Article
- New highlights in cancer and depression multimorbidity: a scoping systematic review.Frontiers in oncology · 2025Review
- The relationship between oxidative balance score, depression, and survival among adult cancer survivors in the United States.Frontiers in nutrition · 2025Article
- Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients.Journal of sport and health science · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDepression is common among breast cancer patients and can affect concordance with guideline-recommended treatment plans. Yet, the impact of depression on cancer treatment and survival is understudied, particularly in relation to the timing of the depression diagnosis.
methodsThe Kentucky Cancer Registry data was used to identify female patients diagnosed with primary invasive breast cancer who were 20 years of age or older in 2007-2011. Patients were classified as having no depression, depression pre-cancer diagnosis only, depression post- cancer diagnosis only, or persistent depression. The impact of depression on receiving guideline-recommended treatment and survival was examined using multivariable logistic regression and Cox regression, respectively.
resultsOf 6054 eligible patients, 4.1%, 3.7%, and 6.2% patients had persistent depression, depression pre-diagnosis only, and depression post-diagnosis only, respectively. A total of 1770 (29.2%) patients did not receive guideline-recommended cancer treatment. Compared to patients with no depression, the odds of receiving guideline-recommended treatment were decreased in patients with depression pre-diagnosis only (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.54-1.04) but not in patients with post-diagnosis only or persistent depression. Depression post-diagnosis only (hazard ratio, 1.51; 95% CI, 1.24-1.83) and depression pre-diagnosis only (hazard ratio, 1.26; 95% CI, 0.99-1.59) were associated with worse survival. No significant difference in survival was found between patients with persistent depression and patients with no depression (p > .05).
conclusionsNeglecting depression management after a breast cancer diagnosis may result in poorer cancer treatment concordance and worse survival. Early detection and consistent management of depression is critical in improving patient survival.
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