ArticleMolecular psychiatry2023
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study.
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Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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17 citing papers in PubMed, 18 citations in OpenAlex.
- An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- A longitudinal DNA methylation atlas and its link to brain structure and mental health.Molecular psychiatry · 2026Article
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- DNA methylation signatures associated with early-onset schizophrenia in Chinese patients.Translational psychiatry · 2026Article
- Childhood Trauma Across the Schizophrenia Spectrum: A Comparison of Schizotypal Personality Disorder and Schizophrenia.Schizophrenia bulletin · 2026Article
- CoxMDS: multiple data splitting for high-dimensional mediation analysis with survival outcomes in epigenome-wide studies.Briefings in bioinformatics · 2026Article
- Associations between childhood trauma, cognitive function, and clinical symptoms in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- The origin patterns, admixture, and selection signatures of the global gamecock populations.Poultry science · 2025Article
- The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach.Psychological medicine · 2025Observational
- Article
- Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approaches.Annals of general psychiatry · 2025Review
- Methylomic signature of current cannabis use in two first-episode psychosis cohorts.Molecular psychiatry · 2025Article
- Maternal epigenetic index links early neglect to later neglectful care and other psychopathological, cognitive, and bonding effects.Clinical epigenetics · 2025Article
- A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis: commentary, Alameda.BJPsych open · 2025Article
- Impacts of Polyenvironmental Factors on DNA Methylation in Patients With Psychosis.Schizophrenia bulletin open · 2025Article
- Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
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Authors and funding
44 authors at 20 institutions in 9 countries.
Luis AlamedaService of General Psychiatry, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital (CHUV), Lausanne, Switzerland. laluisalameda@gmail.com.ORCID 0000-0002-8621-2885
Zhonghua LiuDepartment of Biostatistics, Columbia University, New York, NY, USA.ORCID 0000-0003-3048-9823
Pak C ShamDepartment of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for PanorOmic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Monica AasSocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Giulia TrottaSocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Victoria RodriguezPsychosis Studies, Institute of Psychiatry, Psychology and Neuroscience. King's College of London, London, UK.
Marta Di FortiSocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Simona A StiloDepartment of Mental Health and Addiction Services, ASP Crotone, Crotone, Italy.
Radhika KandaswamySocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.ORCID 0000-0003-3382-4754
Manuel ArrojoDepartment of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain.
Miguel BernardoBarcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Biomedical Research Networking Centre in Mental Health (CIBERSAM), Barcelona, Spain.ORCID 0000-0001-8748-6717
Julio BobesInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.ORCID 0000-0003-2187-4033
Lieuwe de HaanDepartment of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Cristina Marta Del-BenNeuroscience and Behaviour Department, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-0145-9975
Charlotte Gayer-AndersonESRC Centre for Society and Mental Health, King's College London, London, UK.
Lucia SideliLUMSA University, Department of Human Science and Department of Psychosis Studies, KCL, Rome, Italy.
Peter B JonesDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0387-880X
Hannah E JongsmaPsylife Group, Division of Psychiatry, University College London, London, UK.
James B KirkbridePsylife Group, Division of Psychiatry, University College London, London, UK.ORCID 0000-0003-3401-0824
Caterina La CasciaSection of Psychiatry, Department of Biomedicine, Neuroscience and advanced Diagnostic (BiND), University of Palermo, Palermo, Italy.
Antonio LasalviaSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
Sarah TosatoSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.ORCID 0000-0002-9665-7538
Pierre-Michel LlorcaUniversité Clermont Auvergne, Clermont-Ferrand, France.ORCID 0000-0001-7438-8990
Paulo Rossi MenezesDepartment of Preventive Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-6330-3314
Jim van OsPsychosis Studies, Institute of Psychiatry, Psychology and Neuroscience. King's College of London, London, UK.ORCID 0000-0002-7245-1586
Diego QuattroneSocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Bart P RuttenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID 0000-0002-9834-6346
Jose Luis SantosDepartment of Psychiatry, Servicio de Psiquiatría Hos"ital "Virgen de"a Luz", C/Hermandad de Donantes de Sangre, 16002, Cuenca, Spain.
Julio SanjuánDepartment of Psychiatry, School of Medicine, Universidad de Valencia, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), C/Avda. Blasco Ibáñez 15, 46010, Valencia, Spain.
Jean-Paul SeltenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands.
Andrei SzökeUniversity of Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires, H. Mondor, DMU IMPACT, Creteil, France.
Ilaria TarriconeBologna Transcultural Psychosomatic Team (BoTPT), Department of Medical and Surgical Science, Alma Mater Studiorum Università di Bologna, Bologna, Italy.ORCID 0000-0002-5786-2520
Andrea TortelliInstitute Mondor de recherché biomedicale, Creteil, France.
Eva VelthorstGGZ (Mental Health Services) Noord Holland Noord, Heerhugowaard, the Netherlands.ORCID 0000-0002-9240-2909
Craig MorganESRC Centre for Society and Mental Health, King's College London, London, UK.
Emma DempsterDepartment of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0003-1257-5314
Eilis HannonDepartment of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0001-6840-072X
Joe BurrageDepartment of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Daniella DwirDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-4931-9007
Atheeshaan ArumuhamPsychosis Studies, Institute of Psychiatry, Psychology and Neuroscience. King's College of London, London, UK.
Jonathan MillDepartment of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0003-1115-3224
Robin M MurrayPsychosis Studies, Institute of Psychiatry, Psychology and Neuroscience. King's College of London, London, UK.ORCID 0000-0003-0829-0519
Chloe C Y WongSocial, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBMaastricht University Medical Centre · NLUniversidade de São Paulo · BRUniversity College London · GBUniversity of Verona · ITAmsterdam University Medical Centers · NLCentro de Investigación Biomédica en Red de Salud Mental · ESColumbia University · USComplejo Hospitalario Universitario de Santiago · ESGGZ Noord-Holland-Noord · NLHospital General Universitario Gregorio Marañón · ESHospital Virgen de la Luz · ESInserm · FRInstitut Mondor de Recherche Biomédicale · FRIstituto S.Anna Crotone · ITLibera Università Maria SS. Assunta · ITUniversidad de Oviedo · ESUniversitat de València · ESUniversité Clermont Auvergne · FRUniversity of Bologna · IT
Funding
Medical Research Council MR/M008924/1Medical Research Council MR/R005176/1
Abstract
abtractStudies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed. Adversity scores were created for abuse, neglect and composite adversity with the Childhood Trauma Questionnaire (CTQ). Regressions examining (I) CTQ scores with psychosis; (II) with DNAm EWAS level and (III) between DNAm and caseness, adjusted for a variety of confounders were conducted. Divide-Aggregate Composite-null Test for the composite null-hypothesis of no mediation effect was conducted. Enrichment analyses were conducted with missMethyl package and the KEGG database. Our results show that CA was associated with psychosis (Composite: OR = 1.68; p = <0.001; abuse: OR = 2.16; p < 0.001; neglect: OR = 2.27; p = <0.001). None of the CpG sites significantly mediated the adversity-psychosis association after Bonferroni correction (p < 8.1 × 10
Indexed as
Adverse Childhood ExperiencesPsychological TestsPsychotic DisordersSelf ReportChildDNA MethylationEpigenomeHumans
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