Evidence map›Paper›PMID 37062555›Full record

ArticleSaudi medical journal2023

Frequency of the rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in type 2 diabetes mellitus in Saudi Arabia.

Nahla A Alshaikh, Siddig I Abdelwahab, Mahmoud M Habibullah, Ahmed A Jerah, Mohammed A Bakri, Yahia A Kaabi

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In one paragraph

Article in Saudi medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nahla A AlshaikhFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Siddig I AbdelwahabFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Mahmoud M HabibullahFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Ahmed A JerahFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Mohammed A BakriFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Yahia A KaabiFrom Medical Laboratory Technology Department (Alshaikh, Habibullah, Jerah, Kaabi), Faculty of Applied Medical Sciences, Jazan University; from the Medical Research Center (Abdelwahab), Jazan University; and from the Department of Medical Laboratories (Bakri), King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Jazan University · SAKing Fahad Central Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the prevalence of rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in Saudi Arabia and their possible associations with type 2 diabetes mellitus (T2DM).

methodsBlood samples were collected from 428 participants from Jazan University Hospital, Jazan, Saudi Arabia between September 2021 and June 2022 and subjected to TaqMan single-nucleotide polymorphisms (SNP) genotyping assay for rs241703 (G>A) and rs2015 (G>T). Genotype frequencies were determined in control (n=217).

resultsThe A allele of rs2241703 was undetected in our population, and all samples carried the GG genotype. The rs2015 SNP frequency was 29.4% for GG, 45.6% for GT, and 24% for TT. However, logistic regression analysis of the dominant inheritance model showed no association between the T allele and T2DM calculated odds ratio [OR]=0.80, 95% confidence interval=0.53 to 1.20,

conclusionAlthough rs2241703 SNP of Sirtuins 2 is not present, rs2015 SNP is highly prevalent in Saudi Arabia, but no direct link was identified with T2DM.

Indexed as

Diabetes Mellitus, Type 2MicroRNAsCase-Control StudiesGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideSaudi ArabiaSirtuin 2MicroRNAsSIRT2 protein, humanSirtuin 2polymorphismSaudi ArabiaSIRT2T2DM

Identifiers

PMID37062555
PMCPMC10153611
OpenAlexW4366003350

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.