Evidence map›Paper›PMID 37062538›Full record

ArticleAsian spine journal2023

Effects of Epothilone Administration on Locomotion Recovery after Spinal Cord Injury: A Systematic Review of Animal Studies.

Arian Madani Neishaboori, Mohammad Javad Tavallaei, Amirmohammad Toloui, Koohyar Ahmadzadeh, Seyedeh Niloufar Rafiei Alavi, Martin Lauran, Mostafa Hosseini, Mahmoud Yousefifard

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian spine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Arian Madani NeishabooriPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Javad TavallaeiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amirmohammad TolouiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Koohyar AhmadzadehPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Seyedeh Niloufar Rafiei AlaviPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Martin LauranGKT School of Medical Education, King's College London, London, UK.
Mostafa HosseiniDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mahmoud YousefifardPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRKing's College London · GBTehran University of Medical Sciences · IR

Funding

Iran University of Medical Sciences 98-4-99-16778
6 · The paper itself

Abstract

This is a systematic review and meta-analysis of existing evidence regarding the possible effects of epothilones on spinal cord injury (SCI). This study aimed to investigate the possible effects of epothilone administration on locomotion recovery in animal models of SCI. Despite increasing rates of SCI and its burden on populations, no consensus has been reached about the possible treatment modality for SCI. Meanwhile, low-dose epothilones have been reported to have positive effects on SCI outcomes. Electronic databases of Web of Science, Scopus, Embase, and Medline were searched using keywords related to epothilones and SCI until the end of 2020. Two researchers screened the articles, and extracted data were analyzed using STATA ver. 14.0. Final results are reported as a standardized mean difference (SMD) with a 95% confidence interval (CI). After the screening, five studies were included in the analysis. Rats were used in all the studies. Two types of epothilones were used via intraperitoneal injection and were shown to have positive effects on the motor outcomes of samples with SCI (SMD, 0.87; 95% CI, 0.51 to 1.23; p =0.71). Although a slightly better effect was observed when using epothilone B, the difference was not significant (coefficient, -0.50; 95% CI, -1.52 to 0.52; p =0.246). The results of this study suggest that epothilones have positive effects on the improvement of motor function in rats, when administered intraperitoneally until a maximum of 1 day after SCI. However, current evidence regarding the matter is still scarce.

Indexed as

EpothilonesMeta-analysisSpinal cord injuriesTreatment

Identifiers

PMID37062538
PMCPMC10460658
OpenAlexW4366003368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.