Evidence map›Paper›PMID 37062522›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ

Lauren G Poole, Lauren R Schmitt, Anthony Schulte, Dafna J Groeneveld, Holly M Cline, Yaqiu Sang, Woosuk S Hur, Alisa S Wolberg, Matthew J Flick, Kirk C Hansen and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Fibrinogen superfamily proteins: Key regulators in hepatic disorders.World journal of experimental medicine · 2025
    Review
  3. Article
  4. Deconstructing fibrin(ogen) structure.Journal of thrombosis and haemostasis : JTH · 2025
    Review
  5. Fibrinolysis-Mediated Pathways in Acute Liver Injury.Seminars in thrombosis and hemostasis · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lauren G PooleDepartment of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA. Electronic address: https://twitter.com/PoolePAR_ty.
Lauren R SchmittDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Anthony SchulteDepartment of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA.
Dafna J GroeneveldDepartment of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA.
Holly M ClineDepartment of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA.
Yaqiu SangDepartment of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Woosuk S HurDepartment of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alisa S WolbergDepartment of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Matthew J FlickDepartment of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA.
James P LuyendykDepartment of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA. Electronic address: luyendyk@msu.edu.
Michigan State University · USUniversity of North Carolina at Chapel Hill · USUniversity of Colorado Denver · US

Funding

Fibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4M
Novel determinants of fibrinogen pro-repair activity in acetaminophen-induced liver toxicityR01DK120289 · NIDDK · MICHIGAN STATE UNIVERSITY · PI LUYENDYK, JAMES P · 2019 to 2023
$2.2M
Novel coagulation-dependent mechanisms of liver regeneration to detect and prevent liver dysfunction after partial hepatectomyR01DK122813 · NIDDK · MICHIGAN STATE UNIVERSITY · PI LUYENDYK, JAMES P · 2020 to 2024
$2.0M
Fibrin(ogen) control of metabolic inflammation and obesityR01DK112778 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J. · 2019 to 2022
$1.5M
Novel mechanisms linking blood coagulation to liver fibrosisR00DK129710 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI POOLE, LAUREN G · 2023 to 2025
$841k
Quadrupole-Orbitrap Mass SpectrometerS10OD021641 · OD · UNIVERSITY OF COLORADO DENVER · PI HANSEN, KIRK C · 2017 to 2017
$600k
Novel mechanisms linking blood coagulation to liver fibrosisK99DK129710 · NIDDK · MICHIGAN STATE UNIVERSITY · PI POOLE, LAUREN G · 2021 to 2022
$177k
Mechanisms of fibrin(ogen)-directed macrophage activation in liver toxicityF32DK121423 · NIDDK · MICHIGAN STATE UNIVERSITY · PI POOLE, LAUREN G · 2019 to 2019
$62k
NHLBI NIH HHS R01 HL126974NIDDK NIH HHS F32 DK121423NIDDK NIH HHS K99 DK129710NIDDK NIH HHS R00 DK129710NIDDK NIH HHS R01 DK112778NIDDK NIH HHS R01 DK120289NIDDK NIH HHS R01 DK122813NIH HHS S10 OD021641
6 · The paper itself

Abstract

backgroundHepatic deposition of cross-linked fibrin(ogen) occurs alongside platelet accumulation as a hallmark of acetaminophen (APAP)-induced liver injury.

objectivesWe sought to define the precise role of the fibrinogen γ-chain C-terminal integrin α

methodsMice expressing mutant fibrinogen incapable of engaging integrin α

resultsWe observed an altered pattern of fibrin(ogen) deposition in the livers of APAP-challenged Fibγ

conclusionThe results indicate that fibrinogen-γ

Indexed as

AcetaminophenChemical and Drug Induced Liver Injury, ChronicFibrinogenAnimalsFibrinIntegrinsLysineMiceAcetaminophenFgg protein, mouseFibrinFibrinogenIntegrinsLysineacetaminophenacute liver injurycross-linkingfibrinogenmouse model

Identifiers

PMID37062522
PMCPMC10524487
OpenAlexW4366084180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.