Evidence map›Paper›PMID 37062436›Full record

ArticleCellular signalling2023

Reduction of TRPC1/TRPC3 mediated Ca

Samuel Shin, Farai C Gombedza, Eugenia Awuah Boadi, Allen J Yiu, Sanjit K Roy, Bidhan C Bandyopadhyay

Open access · greenAbstract read
In one paragraph

Article in Cellular signalling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. CaNeurochemical research · 2026
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samuel ShinFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America.
Farai C GombedzaFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America.
Eugenia Awuah BoadiFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America.
Allen J YiuFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America.
Sanjit K RoyFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America.
Bidhan C BandyopadhyayFrom Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States of America. Electronic address: bidhan.bandyopadhyay@va.gov.
Veterans Health Administration · US

Funding

Calcium transport in kidney proximal tubule and calcium phosphate stone formationR01DK102043 · NIDDK · INSTITUTE FOR CLINICAL RESEARCH, INC. · PI BANDYOPADHYAY, BIDHAN CHANDRA · 2015 to 2019
$1.1M
NIDDK NIH HHS R01 DK102043
6 · The paper itself

Abstract

Oxidative stress is a predisposing factor in Chronic Obstructive Pulmonary Disease (COPD). Specifically, pulmonary epithelial (PE) cells reduce antioxidant capacity during COPD because of the continuous production of reactive oxygen species (ROS). However, the molecular pathogenesis that governs such ROS activity is unclear. Here we show that the dysregulation of intracellular calcium concentration ([Ca

Indexed as

Calcium ChannelsPulmonary Disease, Chronic ObstructiveCalciumCalcium SignalingExtracellular Signal-Regulated MAP KinasesHumansORAI1 ProteinOxidative StressReactive Oxygen SpeciesStromal Interaction Molecule 1TRPC Cation ChannelsCalciumCalcium ChannelsExtracellular Signal-Regulated MAP KinasesORAI1 ProteinReactive Oxygen SpeciesStromal Interaction Molecule 1transient receptor potential cation channel, subfamily C, member 1TRPC3 cation channelTRPC Cation ChannelsCa(2+) signalingLung diseaseOxidative stressPulmonary epithelial cellsTRPC channel

Identifiers

PMID37062436
PMCPMC10542863
OpenAlexW4365511276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.