Evidence map›Paper›PMID 37062361›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2024

Neural Correlates of the p Factor in Adolescence: Cognitive Control With and Without Enhanced Positive Affective Demands.

Anaïs M Rodriguez-Thompson, Adam Bryant Miller, Mark Wade, Kristin N Meyer, Laura Machlin, Adrienne S Bonar, Kinjal K Patel, Matteo Giletta, Paul D Hastings, Matthew K Nock and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Anaïs M Rodriguez-ThompsonDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: anaisrt@unc.edu.
Adam Bryant MillerDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Mental Health Risk and Resilience Research Program, RTI International, Research Triangle Park, North Carolina.
Mark WadeDepartment of Applied Psychology and Human Development, University of Toronto, Toronto Ontario, Canada.
Kristin N MeyerDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Laura MachlinDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Adrienne S BonarDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kinjal K PatelDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Matteo GilettaDepartment of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium.
Paul D HastingsCenter for Mind and Brain, University of California Davis, Davis, California.
Matthew K NockPsychology Department and Center for Brain Science, Harvard University, Cambridge, Massachusetts.
Karen D RudolphDepartment of Psychology, University of Illinois, Urbana, Illinois.
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California.
Mitchell J PrinsteinDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Margaret A SheridanDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USGhent University · BEHarvard University · USUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of Illinois Urbana-Champaign · USUniversity of Toronto · CA

Funding

Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent GirlsR01MH107479 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NOCK, MATTHEW K, PRINSTEIN, MITCHELL J · 2015 to 2019
$4.6M
Identifying injurious Thoughts and Behaviors in Childhood: A Mixed-Methods InvestigationR01MH115004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHERIDAN, MARGARET ANN · 2018 to 2022
$4.2M
Neural pathways linking early adversity and preschool psychopathology to adolescent mental healthR01MH120314 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARPENTER, KIMBERLY L H, COPELAND, WILLIAM · 2020 to 2024
$3.8M
Training Program in Comparative Effectiveness Research for Suicide PreventionT32MH125815 · NIMH · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN, MATTHEW K NOCK · 2022 to 2026
$1.2M
Testing the predictive power of neural connectivity: Suicidal ideation in youth exposed to maltreatmentK01MH116325 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, ADAM BRYANT · 2018 to 2022
$898k
NICHD NIH HHS P50 HD103573NIMH NIH HHS K01 MH116325NIMH NIH HHS R01 MH107479NIMH NIH HHS R01 MH115004NIMH NIH HHS R01 MH120314NIMH NIH HHS T32 MH125815
6 · The paper itself

Abstract

backgroundRecent research has aimed to characterize processes underlying general liability toward psychopathology, termed the p factor. Given previous research linking the p factor with difficulties in both executive functioning and affective regulation, the present study investigated nonaffective and positive affective inhibition in the context of a sustained attention/inhibition paradigm in adolescents exhibiting mild to severe psychopathology.

methodsFunctional magnetic resonance imaging data were collected during an integrated reward conditioning and go/no-go task in 138 adolescents assigned female at birth. We modeled the p factor using hierarchical confirmatory factor analysis. Positive affective inhibition was measured by examining responses to no-go stimuli with a history of reward conditioning. We examined associations between p factor scores and neural function and behavioral performance.

resultsConsistent with nonaffective executive function as a primary risk factor, p factor scores were associated with worse behavioral performance and hypoactivation in the left superior frontal gyrus and middle frontal gyrus during response initiation (go trials). The p factor scores were additionally associated with increased error-related signaling in the temporal cortex during incorrect no-go trials.

conclusionsDuring adolescence, a period characterized by heightened risk for emergent psychopathology, we observed unique associations between p factor scores and neural and behavioral indices of response initiation, which relies primarily on sustained attention. These findings suggest that shared variation in mental disorder categories is characterized in part by sustained attention deficits. While we did not find evidence that the p factor was associated with inhibition in this study, this observation is consistent with our hypothesis that the p factor would be related to nonaffective control processes.

Indexed as

Executive FunctionPrefrontal CortexAdolescentChildCognitionFemaleFrontal LobeHumansMaleTemporal LobeAdolescenceGo/no-go taskInhibitionp factorPsychopathologySustained attention

Identifiers

PMID37062361
PMCPMC10576014
OpenAlexW4365504804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.