ArticleArchives of gynecology and obstetrics2023
Patient- and cycle-specific factors affecting the outcome of frozen-thawed embryo transfers.
Article in Archives of gynecology and obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Correlation between multiple embryo transfers and the incidence of preterm birth and low birth weight: a network meta-analysis.Archives of gynecology and obstetrics · 2025Article
- Number of top-quality embryos transferred has no advantage in women over the age of 40 in FET cycles.BMC pregnancy and childbirth · 2025Article
- Singleton term pregnancies resulting from frozen-thawed embryo transfer in hormone replacement cycles increase the risk of aberrant placentation, including velamentous umbilical cord insertion.Archives of gynecology and obstetrics · 2025Article
- How to balance the live birth rate and the multiple pregnancy rate by selecting the cleavage-stage embryo number and quality for POSEIDON Group 1 and Group 2? A retrospective study.Archives of gynecology and obstetrics · 2025Article
- Effect of maternal age, embryo number and quality on pregnancy outcome during frozen embryo transfer cycle.Frontiers in endocrinology · 2025Article
- The effect of overnight culture after thawing of D3 cleavage-stage embryos on clinical pregnancy outcomes: focus on embryo development to day 4.Frontiers in endocrinology · 2025Article
- Analysis of factors influencing clinical pregnancy rates in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2025Article
- Pregnancy, delivery, and neonatal outcomes among women with PCOS and endometriosis: a population database cohort.Archives of gynecology and obstetrics · 2024Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study attempted at identifying the main parameters influencing the outcome of frozen embryo transfers.
methodsThis is a single-center retrospective cohort study of 830 frozen-embryo-transfer cycles performed at a German university hospital from January 2012 to December 2016. Main outcome parameters were the clinical pregnancy and live birth rate. Twelve patient- and cycle-dependent factors were analyzed in terms of their influence on the outcome of frozen embryo transfers. Multivariate logistic regression analysis was used for the modelling of the dependency of the different parameters on outcomes.
resultsThe clinical pregnancy rate in our study was 25.5%, the live birth rate was 16.1% with an average maternal age of 34.2 years at the time of the oocyte retrieval. In the univariate analysis age, number of transferred embryos, blastocyst versus cleavage stage transfer, embryo quality and mode of endometrial preparation affected the birth rate significantly. The birth rate after artificial endometrial preparation was significantly lower than the birth rate after transfers in modified natural cycles (12.8 versus 20.6% with p = 0.031). The multivariate logistic regression analysis showed a significant independent influence of age, number of transferred embryos, culture duration and mode of endometrial preparation on the frozen embryo transfer success rates. Body mass index, nicotine abuse, a history of PCO syndrome or endometriosis and the co-transfer of a second poor-quality embryo to a good-quality embryo appeared to be irrelevant for the outcome in our collective.
conclusionAge, number of transferred embryos, embryo culture duration and the mode of endometrial preparation are independent predictive factors of frozen embryo transfer outcomes.
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