Evidence map›Paper›PMID 37061946›Full record

ArticleJournal of the American Society for Mass Spectrometry2023

MALDI IMS-Derived Molecular Contour Maps: Augmenting Histology Whole-Slide Images.

Kavya Sharman, Nathan Heath Patterson, Lukasz G Migas, Elizabeth K Neumann, Jamie Allen, Katherine N Gibson-Corley, Jeffrey M Spraggins, Raf Van de Plas, Eric P Skaar, Richard M Caprioli

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Oversampling for Enhanced Spatial Resolution of Zebrafish by Top-Hat IR-MALDESI-MSI.Journal of the American Society for Mass Spectrometry · 2024
    Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kavya SharmanMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-3487-7199
Nathan Heath PattersonMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0064-1583
Lukasz G MigasDelft Center for Systems and Control, Delft University of Technology, 2628 CD Delft, The Netherlands.ORCID 0000-0002-1884-6405
Elizabeth K NeumannMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-6078-3321
Jamie AllenMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
Katherine N Gibson-CorleyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Jeffrey M SpragginsMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-9198-5498
Raf Van de PlasMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-2232-7130
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Richard M CaprioliMass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-5859-3310

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human KidneyU54DK134302 · NIDDK · VANDERBILT UNIVERSITY · PI SPRAGGINS, JEFFREY M · 2022 to 2025
$7.1M
Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue MappingU54DK120058 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2018 to 2021
$5.7M
Pancreas Organ Specific ProjectU54EY032442 · NEI · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 2020 to 2024
$5.7M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2M
Defining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscessesR01AI145992 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E, SKAAR, ERIC P · 2020 to 2024
$3.8M
Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass SpectrometryR01AG078803 · NIA · VANDERBILT UNIVERSITY · PI Rena A. S. Robinson, Matthew Schrag · 2022 to 2026
$3.5M
NEI NIH HHS U54 EY032442NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI145992NIA NIH HHS R01 AG078803NIDDK NIH HHS P30 DK020593NIDDK NIH HHS U54 DK120058NIDDK NIH HHS U54 DK134302NIEHS NIH HHS T32 ES007028
6 · The paper itself

Abstract

Imaging mass spectrometry (IMS) provides untargeted, highly multiplexed maps of molecular distributions in tissue. Ion images are routinely presented as heatmaps and can be overlaid onto complementary microscopy images that provide greater context. However, heatmaps use transparency blending to visualize both images, obscuring subtle quantitative differences and distribution gradients. Here, we developed a contour mapping approach that combines information from IMS ion intensity distributions with that of stained microscopy. As a case study, we applied this approach to imaging data from

Indexed as

KidneyMicroscopyAlgorithmsAnimalsLipidsMiceSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationLipids

Identifiers

PMID37061946
PMCPMC10787559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.