Evidence map›Paper›PMID 37061728›Full record

ArticleExperimental hematology & oncology2023

Wdr5 is essential for fetal erythropoiesis and hematopoiesis.

Lulu Liu, Yanjia Fang, Xiaodan Ding, Weihua Zhou, Remi Terranova, Yan Zhang, He Wang

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology & oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Lulu LiuNovartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA, USA.
Yanjia FangNovartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai, China.
Xiaodan DingDepartment of Hematology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai, China.
Weihua ZhouNovartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA, USA.
Remi TerranovaNovartis Institutes for BioMedical Research, Kohlenstrasse 44, Novartis Campus, 4056, Basel, Switzerland.
Yan ZhangDepartment of Hematology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai, China. yan.zhang19510@shgh.cn.
He WangNovartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA, USA. he.wang@novartis.com.
Novartis (China) · CNNovartis (United States) · USNovartis (Switzerland) · CHShanghai First People's Hospital · CNShanghai Jiao Tong University · CN

Funding

National Key Research and Development Program of China 2019YFA0111000Science and Technology Commission of Shanghai Municipality of China 19JC1414400
6 · The paper itself

Abstract

WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the function of WDR5 in normal tissues physiologically are quite limited so far. In our study, we explored the function of Wdr5 in erythropoiesis and hematopoiesis by using a hematopoietic-specific Wdr5 knockout mouse model. We found that loss of Wdr5 mediated by Vav-iCre leads to embryonic lethality with defective erythropoiesis. In addition, Wdr5-deficiency completely impairs the hematopoietic stem and progenitor cells function and might alter the immunophenotype of these stem cells and progenitors by decreasing c-Kit expression. Collectively, we identified the pivotal role of Wdr5 in fetal hematopoiesis and erythropoiesis as the de novo findings.

Indexed as

ErythropoiesisHematopoiesisHematopoietic stem cellWdr5

Identifiers

PMID37061728
PMCPMC10105386
OpenAlexW4365812437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.