ArticleAntimicrobial resistance and infection control2023
Hospital sanitary facilities on wards with high antibiotic exposure play an important role in maintaining a reservoir of resistant pathogens, even over many years.
Article in Antimicrobial resistance and infection control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Two clusters of carbapenemase-producing bacteria linked to hospital utility room wastewater drains - an outbreak report.Antimicrobial resistance and infection control · 2026Article
- Seasonality and other factors influencing hospital acquisition of multi-drug-resistant Enterobacterales colonisation: a one-year cohort study - Botswana, 2022-2023.Infection prevention in practice · 2026Article
- DetectingAntibiotics (Basel, Switzerland) · 2026Article
- Hospital Wing Opening Sparks Antimicrobial Resistance in Wastewater Microbial Community Within the First Twelve Months.Microorganisms · 2026Article
- Fingerprinting PCR Reveals Potential Dissemination of Multidrug Efflux System Genes and Antimicrobial Resistance inInternational journal of microbiology · 2026Article
- Persistent multispecies dissemination ofJournal of clinical microbiology · 2025Article
- Multicenter exploration of microbial communities in hospital toilets reveals: antibiotic exposure in a nosocomial settings selects for coEnterococcus over commensal taxa.Antimicrobial resistance and infection control · 2025Article
- Incidence, case-fatality rates and risk factors of bloodstream infections caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- The Antimicrobial Resistance-Water-Corporate Interface: Exploring the Connections Between Antimicrobials, Water, and Pollution.Tropical medicine and infectious disease · 2025Review
- Successful termination of a multi-year wastewater-associated outbreak of NDM-5-carrying E. coli in a hemato-oncological center.Antimicrobial resistance and infection control · 2025Article
- Persistence of OXA-48-producing ST-22Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Sanitary installations and wastewater plumbing as reservoir for the long-term circulation and transmission of carbapenemase producing Citrobacter freundii clones in a hospital setting.Antimicrobial resistance and infection control · 2023Article
- ESKAPEE Pathogen Biofilm Control on Surfaces with ProbioticAntibiotics (Basel, Switzerland) · 2023Review
- Exploring clonality and virulence gene associations in bloodstream infections using whole-genome sequencing and clinical data.Frontiers in cellular and infection microbiology · 2023Article
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17 authors.
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Abstract
backgroundHospitals with their high antimicrobial selection pressure represent the presumably most important reservoir of multidrug-resistant human pathogens. Antibiotics administered in the course of treatment are excreted and discharged into the wastewater system. Not only in patients, but also in the sewers, antimicrobial substances exert selection pressure on existing bacteria and promote the emergence and dissemination of multidrug-resistant clones. In previous studies, two main clusters were identified in all sections of the hospital wastewater network that was investigated, one K. pneumoniae ST147 cluster encoding NDM- and OXA-48 carbapenemases and one VIM-encoding P. aeruginosa ST823 cluster. In the current study, we investigated if NDM- and OXA-48-encoding K. pneumoniae and VIM-encoding P. aeruginosa isolates recovered between 2014 and 2021 from oncological patients belonged to those same clusters.
methodsThe 32 isolates were re-cultured, whole-genome sequenced, phenotypically tested for their antimicrobial susceptibility, and analyzed for clonality and resistance genes in silico.
resultsAmong these strains, 25 belonged to the two clusters that had been predominant in the wastewater, while two others belonged to a sequence-type less prominently detected in the drains of the patient rooms.
conclusionPatients constantly exposed to antibiotics can, in interaction with their persistently antibiotic-exposed sanitary facilities, form a niche that might be supportive for the emergence, the development, the dissemination, and the maintenance of certain nosocomial pathogen populations in the hospital, due to antibiotic-induced selection pressure. Technical and infection control solutions might help preventing transmission of microorganisms from the wastewater system to the patient and vice versa, particularly concerning the shower and toilet drainage. However, a major driving force might also be antibiotic induced selection pressure and parallel antimicrobial stewardship efforts could be essential.
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