Evidence map›Paper›PMID 37061623›Full record

ArticleScientific reports2023

Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma.

Takashi Matsuzuka, Kiyoaki Tsukahara, Seiichi Yoshimoto, Kazuaki Chikamatsu, Akihiro Shiotani, Isao Oze, Yoshiko Murakami, Takeshi Shinozaki, Yuichiro Enoki, Shinichi Ohba and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 1 country.

Takashi MatsuzukaDepartment of Head and Neck Surgery - Otorhinolaryngology, Asahi University Hospital, 3-23 Hashimotocou, Gifu, 500-8523, Japan. tmtzk@hosp.asahi-u.ac.jp.ORCID 0000-0001-6018-6255
Kiyoaki TsukaharaDepartment of Otorhinolaryngology Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Seiichi YoshimotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Kazuaki ChikamatsuDepartment of Otolaryngology Head and Neck Surgery, Gunma University School of Medicine, Maebashi, Japan.
Akihiro ShiotaniDepartment of Otolaryngology Head and Neck Surgery, National Defense Medical College, Tokorozawa, Japan.
Isao OzeDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Yoshiko MurakamiDepartment of Diagnostic Pathology, Nagoya Medical Center, Nagoya, Japan.
Takeshi ShinozakiDepartment of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Yuichiro EnokiDepartment of Head and Neck Oncology / Ear, Nose and Throat, Saitama Medical University International Medical Center, Saitama, Japan.
Shinichi OhbaDepartment of Otorhinolaryngology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Daisuke KawakitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Nobuhiro HanaiDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Yusuke KoideDepartment of Otolaryngology Head and Neck Surgery, Japan Community Health Care Organization Chukyo Hospital, Nagoya, Japan.
Michi SawabeDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Yusuke NakataDepartment of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
Yujiro FukudaDepartment of Otolaryngology Head and Neck Surgery, Kawasaki Medical School, Kurashiki, Japan.
Daisuke NishikawaDepartment of Otorhinolaryngology, Kindai University Nara Hospital, Nara, Japan.
Gaku TakanoDepartment of Otorhinolaryngology, Nagoya City University West Medical Center, Nagoya, Japan.
Takahiro KimuraDepartment of Otolaryngology - Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Keisuke OguriDepartment of Otorhinolaryngology, Konan Kosei Hospital, Konan, Japan.
Hitoshi HirakawaDepartment of Otorhinolaryngology, Head and Neck Surgery, University of the Ryukyus Faculty of Medicine, Okinawa, Japan.
Yasuhisa HasegawaDepartment of Head and Neck Surgery - Otorhinolaryngology, Asahi University Hospital, 3-23 Hashimotocou, Gifu, 500-8523, Japan.
Aichi Cancer Center · JPAsahi University · JPNagoya City University · JPChukyo Hospital · JPGunma University · JPJuntendo University · JPKawasaki Medical School · JPKindai University · JPKonan Kosei Hospital · JPNagoya Medical Center · JPNara Medical University · JPNational Cancer Center Hospital East · JPNational Defense Medical College · JPSaitama Medical University · JPShiga University of Medical Science · JPTokyo Medical University · JPTokyo National Hospital · JPUniversity of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This sentinel node (SN) biopsy trial aimed to assess its effectiveness in identifying predictive factors of micrometastases and to determine whether elective neck dissection is necessary in oral squamous cell carcinoma. This retrospective study included 55 patients from three previous trials, with positive SNs. The relationship between the sizes of the metastatic focus and metastasis in non-sentinel node (NSN) was investigated. Four of the 55 largest metastatic focus were isolated tumor cells, and the remaining 51 were ranged from 0.2 to 15 mm, with a median of 2.6 mm. The difference of prevalence between 46 negative- and 9 positive-NSN was statistically significant with regard to age, long diameter of primary site and number of cases with regional recurrence. In comparing the size of largest metastatic focus dividing the number of positive SN, with metastaic focus range of < 3.0 mm in one-positive SN group, there were 18 (33%) negative-NSN and no positive-NSN. Regarding prognosis, 3-year overall survival rate of this group (n = 18) and other (n = 37) were 94% and 73% (p = 0.04), and 3-year recurrence free survival rate of this group and other were 94% and 51% (p = 0.03), respectively. Absolutely a further prospective clinical trial would be needed, micrometastases may be defined as solitary SN metastasis with < 3.0 mm of metastatic focus, and approximately 33% of neck dissections could be avoided using these criteria.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsHumansLymph Node ExcisionLymph NodesNeoplasm MicrometastasisNeoplasm StagingRetrospective StudiesSentinel Lymph Node BiopsySquamous Cell Carcinoma of Head and Neck

Identifiers

PMID37061623
PMCPMC10105758
OpenAlexW4365816084

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.