Observational studyActa neurochirurgica2023
Can a new noninvasive method for assessment of intracranial pressure predict intracranial hypertension and prognosis?
Observational study in Acta neurochirurgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Intracranial Pressure Estimation Using B4C Device: A Systematic Review on the Validation Studies.Neurocritical care · 2026Review
- Practicalities of noninvasive neuromonitoring in intensive care.Neurocritical care · 2026Article
- First-in-Human Prospective, Observational, and Comparative Clinical Study of Simultaneous Invasive and Non-Invasive Intracranial Pressure Pulse Wave Monitoring.Sensors (Basel, Switzerland) · 2026Observational
- Performance of Intracranial Pressure Waveform Morphological Features as Biomarkers of Intracranial Hypertension.Critical care explorations · 2026Article
- Commentary: Invasive and Noninvasive Intracranial Pressure Pulse Waveform in Neurocritical Care Patients with Different Cranium Integrity.Neurocritical care · 2026Article
- Systematic review of the diagnostic accuracy of noninvasive intracranial pressure monitoring using optic nerve sheath diameter and the Brain4Care system.Brain & spine · 2026Review
- Non-invasive intracranial pressure monitoring in management of slit ventricle syndrome-case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Evolving concepts in intracranial pressure monitoring - from traditional monitoring to precision medicine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Assessment of brain compliance in patients with migraine: use of non-invasive intracranial monitoring in outpatient clinics.Frontiers in neurology · 2025Article
- Prospective comparative clinical trials of novel non-invasive intracranial pressure pulse wave monitoring technologies: preliminary clinical data.Interface focus · 2024Article
- An ultrasensitive multimodal intracranial pressure biotelemetric system enabled by exceptional point and iontronics.Nature communications · 2024Article
- ICP wave morphology as a screening test to exclude intracranial hypertension in brain-injured patients: a non-invasive perspective.Journal of clinical monitoring and computing · 2024Article
- Noninvasive intracranial pressure profile in 31 patients submitted to fullendoscopic spine surgery.Acta cirurgica brasileira · 2024Article
- Multimodal monitoring intracranial pressure by invasive and noninvasive means.Scientific reports · 2023Article
- A Deep Learning-Based Automated Framework for Subpeak Designation on Intracranial Pressure Signals.Sensors (Basel, Switzerland) · 2023Article
- A new noninvasive method can effectively assess intracranial compliance. Letter to the Editor.Acta neurochirurgica · 2023Article
- Beyond pressure: intracranial compliance and retinal biomarkers in idiopathic normal pressure hydrocephalus.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIndividuals with TBI are at risk of intracranial hypertension (ICH), and monitoring of intracranial pressure (ICP) is usually indicated. However, despite many new noninvasive devices, none is sufficiently accurate and effective for application in clinical practice, particularly in the management of TBIs. This study aimed to compare the noninvasive Brain4Care system (nICP) with invasive ICP (iICP) curve parameters in their ability to predict ICH and functional prognosis in severe TBI.
methodsObservational, descriptive-analytical, and prospective study of 22 patients between 2018 and 2021, simultaneously monitored with nICP and iICP. The independent variables evaluated were the presence of ICH and functional prognoses. The dependent variables were the P2/P1 pressure ratio metrics, time to peak (TTP), and TTP × P2/P1.
resultsWe found a good nonlinear correlation between iICP and nICP waveforms, despite a moderate Pearson's linear correlation. The noninvasive parameters of P2/P1, P2/P1 × TTP, and TTP were not associated with outcomes or ICH. The nICP P2/P1 ratio showed sensitivity/specificity/accuracy (%) of 100/0/56.3, respectively for 1-month outcomes and 77.8/22.2/50 for 6-month outcomes. The nICP TTP ratio had values of 100/0/56.3 for 1-month and 99.9/42.9/72.2 for 6-month outcomes. The nICP P2/P1 × TTP values were 100/0/56.3 for 1-month outcomes and 81.8/28.6/61.1 for 6-month outcomes.
conclusionBrain4Care's noninvasive method showed low specificity and accuracy and cannot be used as the sole means of monitoring ICP in patients with severe TBI. Future studies with a larger sample of patients with P2 > P1 and new nICP curve parameters are warranted.
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