ArticleScientific reports2023
Hippocampal inactivation during rearing on hind legs impairs spatial memory.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prenatal and Lactation Exposure to Bisphenol A (BPA) at the Global Mean Daily Intake Level Leads to Sex-Dependent Changes in Microglial State, Gene Expression, and Behavioral Patterns in Newborn and Juvenile Wistar Rat Offspring.Life (Basel, Switzerland) · 2026Article
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- Effects of Electrical Stimulation of Raphe Magnus on Locomotion and Selected Cognitive Abilities in Rats.International journal of molecular sciences · 2026Article
- Rearing and Head Scanning as Functionally Equivalent Information-Seeking Behaviors.bioRxiv : the preprint server for biology · 2026Article
- Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Ethical Issues in Memory Modification Technology: A Scoping Review.Journal of bioethical inquiry · 2025Article
- Rearing Behavior as Indicator of Spatial Novelty and Memory in Developing Rats.The European journal of neuroscience · 2025Article
- rTCT: Rodent Triangle Completion Task to facilitate translational study of path integration.bioRxiv : the preprint server for biology · 2025Article
- Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cholinergic modulation of rearing in rats performing a spatial memory task.The European journal of neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Spatial memory requires an intact hippocampus. Hippocampal function during epochs of locomotion and quiet rest (e.g., grooming and reward consumption) has been the target of extensive study. However, during navigation rats frequently rear up onto their hind legs, and the importance of hippocampal activity during these periods of attentive sampling for spatial memory is unknown. To address this, we tested the necessity of dorsal hippocampal activity during rearing epochs in the study phase of a delayed win-shift task for memory performance in the subsequent test phase. Hippocampal activity was manipulated with closed-loop, bilateral, optogenetic inactivation. Spatial memory accuracy was significantly and selectively reduced when the dorsal hippocampus was inactivated during rearing epochs at encoding. These data show that hippocampal activity during periods of rearing can be important for spatial memory, revealing a novel link between hippocampal function during epochs of rearing and spatial memory.
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