Evidence map›Paper›PMID 37061178›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2023

Septal annular dilation in chronic ovine functional tricuspid regurgitation.

Artur Iwasieczko, Tomasz Jazwiec, Manikantam Gaddam, Boguslaw Gaweda, Magdalena Piekarska, M Solarewicz, Manuel K Rausch, Tomasz A Timek

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.Cardiovascular engineering and technology · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Artur IwasieczkoDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich; Clinical Department of Cardiac Surgery, St Jadwiga Provincial Clinical Hospital, Rzeszow, Poland.
Tomasz JazwiecDepartment of Cardiac Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Manikantam GaddamDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich.
Boguslaw GawedaDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich; Clinical Department of Cardiac Surgery, St Jadwiga Provincial Clinical Hospital, Rzeszow, Poland.
Magdalena PiekarskaDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich.
M SolarewiczDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich.
Manuel K RauschDepartments of Aerospace Engineering & Engineering Mechanics, Biomedical Engineering, University of Texas at Austin, Austin, Tex.
Tomasz A TimekDivision of Cardiothoracic Surgery, Corewell Health, Grand Rapids, Mich. Electronic address: Tomasz.Timek@corewellhealth.org.
Corewell HealthFoundation of Cardiac Surgery Development · PLMedical University of Silesia · PLNorthwell Health · USThe University of Texas at Austin · US

Funding

Using an Electrospun Surrogate Model to Investigate Mechanisms of Tricuspid Valve MaladaptationR01HL165251 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI MANUEL Karl RAUSCH · 2022 to 2026
$4.3M
Human-Specific Prediction, Training, and Visualization Tools for the Tricuspid Valve from Existing DataR21HL161832 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI RAUSCH, MANUEL KARL · 2022 to 2023
$222k
NHLBI NIH HHS R01 HL165251NHLBI NIH HHS R21 HL161832
6 · The paper itself

Abstract

introductionAnnular reduction with prosthetic rings represents the current surgical treatment of functional tricuspid regurgitation (FTR). However, alterations of annular geometry and dynamics associated with FTR are not well characterized.

methodsFTR was induced in 29 adult sheep with either 8 weeks of pulmonary artery banding (PAB, n = 15) or 3 weeks of tachycardia-induced cardiomyopathy (TIC, n = 14). Eight healthy sheep served as controls (CTL). At the terminal procedure, all animals underwent sternotomy, epicardial echocardiography, and implantation of sonomicrometry crystals on the tricuspid annulus (TA) and right ventricular free wall while on cardiopulmonary bypass. Simultaneous hemodynamic, sonomicrometry, and echocardiographic data were acquired after weaning from cardiopulmonary bypass and stabilization. Annular geometry and dynamics were calculated from 3-dimensional crystal coordinates.

resultsMean FTR grade (0-4) was 3.2 ± 1.2 and 3.2 ± 0.5 for PAB and TIC, respectively, with both models of FTR associated with similar degree of right ventricular dysfunction (right ventricular fractional area contraction 38 ± 7% and 37 ± 9% for PAB and TIC, respectively). Left ventricular ejection fraction was significantly reduced in TIC versus baseline (33 ± 9%, vs 58 ± 4%, P = .0001). TA area was 651 ± 109 mm

conclusionsOvine FTR was associated with annular dilation and reduced annular area contraction. Significant dilation of septal annulus was observed in both models of FTR. As tricuspid rings do not completely stabilize the septal annulus, continued remodeling may contribute to recurrent FTR after repair.

Indexed as

Tricuspid Valve InsufficiencyAnimalsDilatationSheepStroke VolumeTricuspid ValveVentricular Function, Leftfunctional tricuspid regurgitationtricuspid valvevalve repair

Identifiers

PMID37061178
PMCPMC11088945
OpenAlexW4365517960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.