ArticleOphthalmology. Retina2023
Macular Perfusion Deficits on OCT Angiography Correlate with Nonperfusion on Ultrawide-field Fluorescein Angiography in Diabetic Retinopathy.
Article in Ophthalmology. Retina, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 27 citations in OpenAlex.
- Outer Retinal Volume on Macular OCT Predicts Two-Year Diabetic Retinopathy Progression.Investigative ophthalmology & visual science · 2026Observational
- Baseline Deep Capillary Plexus Ischemia Predicts Earlier Diabetic Retinopathy Complications Than Foveal Avascular Enlargement.American journal of ophthalmology · 2026Article
- Effect of Korean red ginseng on deep capillary plexus parameters in diabetic retinopathy: A prospective, randomized, double-blind clinical trial.Journal of ginseng research · 2026Article
- Retinal Ischemic Perivascular Lesions Screen for Vision-Threatening Diabetic Retinopathy Visualized on Ultra-Widefield Fluorescein Angiography.Translational vision science & technology · 2026Article
- Macular, Peripapillary, and Midperipheral Nonperfusion in Diabetic Subjects: A Wide-Field OCTA Quantification.Translational vision science & technology · 2026Article
- Baseline Nonperfusion and Deep Capillary Plexus Ischemia Predict Two-Year Retinal Nonperfusion Progression in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2026Observational
- Macular Microaneurysms Are Associated With Chronic Kidney Disease and Deep Capillary Plexus Ischemia in Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Quantitative comparison of a novel wide-field OCT-angiography device with ultrawide-field fluorescein angiography in detecting retinal nonperfusion in vascular retinopathies.BMC ophthalmology · 2025Article
- Macular Deep Capillary Plexus Ischemia as a Biomarker for Identifying Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Understanding How Low Luminance Visual Deficit Progresses With Advancing Diabetic Macular Ischemia and Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- The Importance of Matching Optical Coherence Tomography Angiography Metrics to Diabetic Retinopathy Severity for Detecting Progression.Investigative ophthalmology & visual science · 2025Observational
- Foveal Avascular Zone Enlargement Correlates with Visual Acuity Decline in Patients with Diabetic Retinopathy.Ophthalmology. Retina · 2025Article
- Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.Investigative ophthalmology & visual science · 2025Article
- The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis.Translational vision science & technology · 2025Article
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Posterior Retinal Ischemia Correlates With Vision in Patients With Diabetes.Investigative ophthalmology & visual science · 2025Observational
- Optical coherence tomography retinal imaging: narrative review of technological advancements and clinical applications.Annals of translational medicine · 2025Review
- Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion: A Prospective Cohort Study.Journal of imaging · 2025Article
- Predictors of Peripheral Retinal Non-Perfusion in Clinically Significant Diabetic Macular Edema.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the correlation between nonperfusion parameters on OCT angiography (OCTA) and ultrawide-field fluorescein angiography (UWF-FA) in subjects with diabetes mellitus (DM).
designProspective, cross-sectional study. SUBJECTS: Subjects with DM and a wide range of diabetic retinopathy (DR) severity seen at a tertiary referral center.
methodsWe used averaged 3 × 3 mm OCTA scans to measure geometric perfusion deficit (GPD), vessel density, and vessel length density in the full retina, superficial capillary plexuses (SCPs), and deep capillary plexuses (DCPs). Nonperfusion was manually delineated on UWF-FA to quantify central, peripheral, and total retinal nonperfusion (mm
main outcome measuresCorrelation between OCTA parameters and UWF-FA nonperfusion, and accuracy of these OCTA and UWF-FA parameters in detecting clinically referable eyes, using receiver operating characteristic (ROC) curve analysis, sensitivity, specificity, and area under the ROC curve (AUC).
resultsThe study included 67 eyes (12 eyes with no signs of DR, 8 mild, 22 moderate, 14 severe nonproliferative DR, and 11 treatment-naive proliferative DR). There was a fair-to-moderate correlation between either central or total retinal nonperfusion on UWF-FA (mm
conclusionsNonperfusion as quantified on OCTA (3 × 3 mm) correlated with UWF-FA parameters and both were comparable in detecting referable DR. These macular OCTA metrics, particularly DCP GPD, have the potential for gauging the overall ischemic status of the retina, with an important clinical role in identifying eyes with clinically referable DR. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.