Evidence map›Paper›PMID 37061021›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2023

Brain-gut microbiome profile of neuroticism predicts food addiction in obesity: A transdiagnostic approach.

Xiaobei Zhang, Ravi R Bhatt, Svetoslav Todorov, Arpana Gupta

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Artificial Intelligence-Empowered Multimodal Learning in Psychiatry: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Xiaobei ZhangG. Oppenheimer Center for Neurobiology of Stress & Resilience, at UCLA, United States of America; UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, United States of America; David Geffen School of Medicine at UCLA, United States of America; University of California, Los Angeles, United States of America.
Ravi R BhattImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, United States of America.
Svetoslav TodorovG. Oppenheimer Center for Neurobiology of Stress & Resilience, at UCLA, United States of America.
Arpana GuptaG. Oppenheimer Center for Neurobiology of Stress & Resilience, at UCLA, United States of America; UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, United States of America; David Geffen School of Medicine at UCLA, United States of America; Goodman-Luskin Microbiome Center at UCLA, United States of America; University of California, Los Angeles, United States of America. Electronic address: agupta@mednet.ucla.edu.
University of California, Los Angeles · USUCLA Health · USUniversity of Southern California · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican AmericanR01MD015904 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2021 to 2025
$4.1M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
NCATS NIH HHS UL1 TR001881NIDDK NIH HHS K23 DK106528NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R03 DK121025NIMHD NIH HHS R01 MD015904
6 · The paper itself

Abstract

Neuroticism is one of the most robust risk factors for addictive behaviors including food addiction (a key contributor to obesity), although the associated mechanisms are not well understood. A transdiagnostic approach was used to identify the neuroticism-related neuropsychological and gut metabolomic patterns associated with food addiction. Predictive modeling of neuroticism was implemented using multimodal features (23 clinical, 13,531 resting-state functional connectivity (rsFC), 336 gut metabolites) in 114 high body mass index (BMI ≥25 kg/m

Indexed as

Behavior, AddictiveFood AddictionGastrointestinal MicrobiomeBrainCross-Sectional StudiesHumansNeuroticismObesityBrain-gut-microbiomeFood addictionMachine learningNeuroticismOmics

Identifiers

PMID37061021
PMCPMC10731989
OpenAlexW4365458414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.