Evidence map›Paper›PMID 37060844›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus.

Michael W K Fong, Kelly Pu, Rakesh Jadav, Tasleema Khan, Lawrence J Hirsch, Hitten P Zaveri

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Michael W K FongComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Westmead Comprehensive Epilepsy Unit, Westmead Hospital, University of Sydney, Sydney, Australia. Electronic address: Michael.Fong@yale.edu.
Kelly PuComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Rakesh JadavComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Manipal Hospitals, Bengaluru, India.
Tasleema KhanComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; University of Maryland Medical Center, Baltimore, Maryland, USA.
Lawrence J HirschComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Hitten P ZaveriComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Yale University · USThe University of Sydney · AUUniversity of Maryland, Baltimore · US

Funding

Network analysis for epilepsy surgeryR01NS109062 · NINDS · YALE UNIVERSITY · PI EID, TORE, ZAVERI, HITTEN P · 2019 to 2022
$1.5M
NINDS NIH HHS R01 NS109062
6 · The paper itself

Abstract

objectiveTo determine whether quantitative EEG analysis of burst suppression can predict seizure recurrence in patients with refractory status epilepticus (RSE) being treated with anesthetic doses of continuous IV antiseizure medications (cIVASM).

methodsQuantitative assessment of burst suppression (including epileptiform discharges [EDs] and evolution) in 31 occasions (from 27 patients), and correlation with seizure recurrence up to 48 hours post sedative wean.

resultsOccasions resulting in seizure recurrence (vs. no seizure recurrence) had lower burst (8.4 vs. 10.6 µV) and interburst interval (IBI) (4.2 vs. 4.8 µV) average amplitude, duration (bursts 2.8 vs. 3.6 s: IBIs 3.6 vs. 4.4 s); and burst total power (0.4 vs. 0.7 µV

conclusionsFor patients in burst suppression, successful wean of cIVASM was not determined by classical burst suppression measures, but instead how "epileptiform" bursts and IBIs were, as determined by EDs in both bursts and IBIs and surrogates for evolution within bursts. SIGNIFICANCE: If confirmed, these objective measures could be used during clinical care to help determine when to wean cIVASM in patients with RSE.

Indexed as

ElectroencephalographyStatus EpilepticusHumansHypnotics and SedativesSeizuresHypnotics and SedativesBurst suppressionHighly-epileptiform bursts (HEBs)Quantitative EEGStatus epilepticus

Identifiers

PMID37060844
PMCPMC11265649
OpenAlexW4361228556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.