Evidence map›Paper›PMID 37060842›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Dependence of cortical neuronal strength-duration properties on TMS pulse shape.

Parvathi Menon, Nathan Pavey, Aman S Aberra, Mehdi A J van den Bos, Ruochen Wang, Matthew C Kiernan, Angel V Peterchev, Steve Vucic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Abnormalities of cortical stimulation strength-duration time constant in amyotrophic lateral sclerosis.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Parvathi MenonBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
Nathan PaveyBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
Aman S AberraDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Mehdi A J van den BosBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
Ruochen WangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Matthew C KiernanBrain and Mind Centre, University of Sydney, Australia.
Angel V PeterchevDepartment of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Psychiatry and Behavioural Sciences, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA; Department of Neurosurgery, Duke University, Durham, NC, USA. Electronic address: angel.peterchev@duke.edu.
Steve VucicBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia. Electronic address: steve.vucic@sydney.edu.au.

Funding

Robotically-actuated, low-noise, concurrent TMS-EEG-fMRI systemR01MH127104 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIU, CHUNLEI, LUSTIG, MICHAEL · 2021 to 2024
$6.5M
Biology and Biophysics of the Cortical Response to Transcranial Magnetic StimulationR01NS117405 · NINDS · DUKE UNIVERSITY · PI PETERCHEV, ANGEL V, SOMMER, MARC A · 2020 to 2024
$3.3M
NeuroSimNIBS: Integrated electric field and neuronal response modeling for transcranial electric and magnetic stimulationR01MH128422 · NIMH · DUKE UNIVERSITY · PI Warren M. Grill, Angel V Peterchev · 2022 to 2026
$2.7M
MPS-TMS: Modular Pulse Synthesizer for Transcranial Magnetic Stimulation with Fully Adjustable Pulse Shape and SequenceTBDRF1MH124943 · NIMH · DUKE UNIVERSITY · PI PETERCHEV, ANGEL V · 2020 to 2020
$1.6M
NIMH NIH HHS R01 MH127104NIMH NIH HHS R01 MH128422NIMH NIH HHS RF1 MH124943NINDS NIH HHS R01 NS117405
6 · The paper itself

Abstract

objectiveThe aim of present study was to explore the effects of different combinations of transcranial magnetic stimulation (TMS) pulse width and pulse shape on cortical strength-duration time constant (SDTC) and rheobase measurements.

methodsResting motor thresholds (RMT) at pulse widths (PW) of 30, 45, 60, 90 and 120 µs and M-ratios of 0.2, 0.1 and 0.025 were determined using figure-of-eight coil with initial posterior-to-anterior induced current. The M-ratio indicates the relative phases of the induced current with lower values signifying a more unidirectional stimulus. Strength-duration time constant (SDTC) and rheobase were estimated for each M-ratio and various PW combinations. Simulations of biophysically realistic cortical neuron models assessed underlying neuronal populations and physiological mechanisms mediating pulse shape effects on strength-duration properties.

resultsThe M-ratio exerted significant effect on SDTC (F

conclusionsCortical strength-duration curve properties vary with pulse shape, and the modulating effect of the hyperpolarising pulse phase on cortical axonal transient Na SIGNIFICANCE: The dependence of the cortical strength-duration curve properties on the TMS pulse shape and pulse width selection underscores the need for consistent measurement methods across studies and the potential to extract information about pathophysiological processes.

Indexed as

NeuronsTranscranial Magnetic StimulationAxonsEvoked Potentials, MotorHeart RateHumansSarcosineThiocarbamatesSarcosinesarcosine dithiocarbamateThiocarbamatescTMSRheobaseSDTCSodium channelStrength-duration time constant

Identifiers

PMID37060842
PMCPMC10280814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.