Evidence map›Paper›PMID 37060806›Full record

ReviewSeminars in immunology2023

Immunity to pathogenic fungi in the eye.

Serena Abbondante, Sixto M Leal, Heather L Clark, Bridget Ratitong, Yan Sun, Li-Jun Ma, Eric Pearlman

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Sulfur Vacancy-Rich MoSAdvanced healthcare materials · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. From fields to eyes: the epidemiology and immune challenges of fungal keratitis.Frontiers in cellular and infection microbiology · 2026
    Article
  9. Chelidonic acid amelioratesFrontiers in immunology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Virulence ofbioRxiv : the preprint server for biology · 2025
    Article
  15. Antifungal susceptibility, clinical findings, and biofilm resistance of Fusarium species causing keratitis: a challenge for disease control.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  16. Article
  17. Article
  18. Frontiers in cellular and infection microbiology · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Serena AbbondanteDepartment of Ophthalmology, and Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
Sixto M LealDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Heather L ClarkUniversity of Rochester Medical Center, Rochester NY, USA.
Bridget RatitongDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yan SunDepartment of Ophthalmic Research, Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Li-Jun MaDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.
Eric PearlmanDepartment of Ophthalmology, and Department of Physiology and Biophysics, University of California, Irvine, CA, USA. Electronic address: eric.pearlman@uci.edu.
University of California, Irvine · USCedars-Sinai Medical Center · USCleveland Clinic Lerner College of Medicine · USUniversity of Alabama at Birmingham · USUniversity of Massachusetts Amherst · USUniversity of Rochester Medical Center · US

Funding

Pathogenesis of Fungal KeratitisR01EY018612 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2008 to 2022
$6.9M
Immunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4M
Identify virulence factors that facilitate Fusarium keratitisR01EY030150 · NEI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MA, LI-JUN · 2019 to 2023
$1.9M
NEI NIH HHS R01 EY018612NEI NIH HHS R01 EY030150NIAID NIH HHS T32 AI089474
6 · The paper itself

Abstract

Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.

Indexed as

FusariumKeratitisCorneaFungiHumansNeutrophilsAspergillusCandidaCorneaCytokinesFungal infectionFusariumIL-1 alphaIL-1 betaInnate immunityKeratitisNADPH oxidaseNeutrophilNutritional immunityOcular infectionReactive oxygen species

Identifiers

PMID37060806
PMCPMC10508057
OpenAlexW4365455942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.