Evidence map›Paper›PMID 37060531›Full record

Observational studyEsophagus : official journal of the Japan Esophageal Society2023

Safety and efficacy of endoscopic submucosal dissection for superficial esophageal cancer with esophageal varices.

Tatsuya Nakai, Tetsuya Yoshizaki, Shinwa Tanaka, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi and 6 more

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Esophagus : official journal of the Japan Esophageal Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Tatsuya NakaiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan.
Tetsuya YoshizakiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan. yoshizak@med.kobe-u.ac.jp.ORCID 0000-0003-4315-4766
Shinwa TanakaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan.
Yoshinobu YamamotoDepartment of Gastroenterological Oncology, Hyogo Cancer Center, Akashi, Japan.
Tomoya SakoDepartment of Gastroenterology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yasuaki KitamuraDepartment of Gastroenterology, Yodogawa Christian Hospital, Osaka, Japan.
Takayuki OseDepartment of Gastroenterology, Kita-Harima Medical Center, Ono, Japan.
Tsukasa IshidaDepartment of Gastroenterology, Akashi Medical Center, Akashi, Japan.
Atsushi IkedaDepartment of Gastroenterology, Sanda City Hospital, Sanda, Japan.
Ryusuke AriyoshiDepartment of Gastroenterology, Steel Memorial Hirohata Hospital, Himeji, Japan.
Mineo IwatateDepartment of Gastroenterology, Sano Hospital, Kobe, Japan.
Fumiaki KawaraDepartment of Gastroenterology, Konan Medical Center, Kobe, Japan.
Toshitatsu TakaoDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan.
Yoshinori MoritaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan.
Takashi ToyonagaDepartment of Endoscopy, Kobe University Hospital, Kobe, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki‑cho, Chuo‑ku, Kobe, Hyogo, 650‑0017, Japan.
Kobe University · JPAkashi Medical Center · JPHyogo Prefectural Cancer Center · JPKobe University Hospital · JPNippon Steel Yawata Memorial Hospital · JPSaiseikai Nakatsu Hospital · JPSanden (Japan) · JPTokyo-Kita Medical Center · JPYodogawa Christian Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeavy drinking is associated with esophageal cancer and esophageal varices. However, there are limited reports of endoscopic resection for esophageal cancer with esophageal varices. In this multicenter study, we clarified the safety and efficacy of endoscopic submucosal dissection for superficial esophageal cancer with esophageal varices.

methodsIn this multicenter, retrospective, observational study, patients underwent esophageal endoscopic submucosal dissection at 10 referral centers in Japan from January 2013 to December 2019. We analyzed characteristics including backgrounds and varices, treatment outcomes, and adverse events in cases with esophageal varices.

resultsA total of 1708 patients were evaluated, 27 (1.6%) of whom had esophageal varices. In patients with esophageal varices, the en bloc resection rate and R0 resection rate were 100% and 77.8%, respectively. Patients with esophageal varices had longer procedure times than patients without esophageal varices (p = 0.015). There was no significant difference in adverse events. There was no significant difference in procedure time and number of adverse events between patients who underwent pretreatment and those who did not. There was no significant difference in these outcomes for patients with lesions on varices compared to those without. Child-Pugh classification and location of the lesions also did not affect these outcomes.

conclusionsEsophageal cancer with esophageal varices could be treated endoscopically safely and effectively.

Indexed as

Endoscopic Mucosal ResectionEsophageal and Gastric VaricesEsophageal NeoplasmsVaricose VeinsHumansRetrospective StudiesAdverse eventEndoscopic submucosal dissectionEsophageal cancerEsophageal varicesProcedure time

Identifiers

PMID37060531
OpenAlexW4365810761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.