Evidence map›Paper›PMID 37060487›Full record

ReviewTissue engineering and regenerative medicine2023

Nanomaterial-Based Scaffolds for Tissue Engineering Applications: A Review on Graphene, Carbon Nanotubes and Nanocellulose.

Gurshagan Kandhola, Sunho Park, Jae-Woon Lim, Cody Chivers, Young Hye Song, Jong Hoon Chung, Jangho Kim, Jin-Woo Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tissue engineering and regenerative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  4. Article
  5. Review
  6. A Mussel-Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Bio-Inspired and Protein-Based Elastomeric Materials.Polymer science & technology (Washington, D.C.) · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gurshagan Kandhola *Department of Biological and Agricultural Engineering, University of Arkansas, Fayetteville, AR, USA.
Sunho Park *Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Jae-Woon LimDepartment of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Cody ChiversDepartment of Biological and Agricultural Engineering, University of Arkansas, Fayetteville, AR, USA.
Young Hye SongDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR, USA.
Jong Hoon ChungDepartment of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Jangho KimDepartment of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea. rain2000@jnu.ac.kr.
Jin-Woo KimDepartment of Biological and Agricultural Engineering, University of Arkansas, Fayetteville, AR, USA. jwkim@uark.edu.ORCID 0000-0002-7119-8208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoscale biomaterials have garnered immense interest in the scientific community in the recent decade. This review specifically focuses on the application of three nanomaterials, i.e., graphene and its derivatives (graphene oxide, reduced graphene oxide), carbon nanotubes (CNTs) and nanocellulose (cellulose nanocrystals or CNCs and cellulose nanofibers or CNFs), in regenerating different types of tissues, including skin, cartilage, nerve, muscle and bone. Their excellent inherent (and tunable) physical, chemical, mechanical, electrical, thermal and optical properties make them suitable for a wide range of biomedical applications, including but not limited to diagnostics, therapeutics, biosensing, bioimaging, drug and gene delivery, tissue engineering and regenerative medicine. A state-of-the-art literature review of composite tissue scaffolds fabricated using these nanomaterials is provided, including the unique physicochemical properties and mechanisms that induce cell adhesion, growth, and differentiation into specific tissues. In addition, in vitro and in vivo cytotoxic effects and biodegradation behavior of these nanomaterials are presented. We also discuss challenges and gaps that still exist and need to be addressed in future research before clinical translation of these promising nanomaterials can be realized in a safe, efficacious, and economical manner.

Indexed as

GraphiteNanostructuresNanotubes, CarbonCelluloseTissue EngineeringCelluloseGraphiteNanotubes, CarbonCarbon nanotubesCellulose nanocrystalsCellulose nanofibersGrapheneRegenerative medicineTissue engineering

Identifiers

PMID37060487
PMCPMC10219911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.