Evidence map›Paper›PMID 37060473›Full record

ArticleJournal of cancer research and clinical oncology2023

Anxiety in patients with gastrointestinal cancer undergoing primary surgery.

Jens Harms, Benedikt Kunzmann, Jan Bredereke, Lea Harms, Thomas Jungbluth, Tanja Zimmermann

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06496438 (Psychobiotics Ameliorate Anxiety and Depression Status in Patients Under Chemotherapy for Gastrointestinal Malignancies), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06496438 naunknown statusnot on this map

Psychobiotics Ameliorate Anxiety and Depression Status in Patients Under Chemotherapy for Gastrointestinal Malignancies

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2023 to 2025Enrolled270ConditionsDepression, Anxiety Disorder, Probiotics, Gastrointestinal CancerArmsPsychobiotics, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Roy adaptation model-based patient education for elderly patients undergoing laparoscopic radical gastrectomy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  5. Trial
  6. Trial
  7. Mindfulness Meditation Reduces Stress and Hospital Stay in Gastrointestinal Tumor Patients During Perioperative Period.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Dynamic screening for anxiety and depression in patients undergoing primary surgery for gastrointestinal cancer.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Characterizing the post-traumatic growth trajectory in gastric cancer survivors: a population-based longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jens HarmsDepartment of Abdominal and Visceral Surgery, Klinikum Wolfsburg, Sauerbruchstrasse 7, 38140, Wolfsburg, Germany.
Benedikt KunzmannDepartment of Abdominal and Visceral Surgery, Klinikum Wolfsburg, Sauerbruchstrasse 7, 38140, Wolfsburg, Germany.
Jan BrederekeDepartment of Psychosomatic Medicine and Psychotherapy, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Lea HarmsDepartment of Gynecology and Obstetrics, Columbia University of New York, New York, USA.
Thomas JungbluthDepartment of Abdominal and Visceral Surgery, Klinikum Wolfsburg, Sauerbruchstrasse 7, 38140, Wolfsburg, Germany.
Tanja ZimmermannDepartment of Psychosomatic Medicine and Psychotherapy, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Zimmermann.Tanja@mh-hannover.de.ORCID http://orcid.org/0000-0002-5069-7278
Fraunhofer Project Centre Wolfsburg · DEMedizinische Hochschule Hannover · DEColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnxiety in the perioperative period is not only an unpleasant emotional state, but can also negatively affect the outcomes and quality of life of surgical patients. The present study investigated anxiety in patients with gastrointestinal cancer scheduled for primary surgery.

methodsA total of 101 patients in four non-university surgical departments were included. Anxiety (GAD-7), depression (PHQ-9), distress (Distress thermometer), and illness perception (Brief IPQ) were assessed at four time points: first outpatient contact before surgery (t1), preoperative inpatient contact (t2), postoperative inpatient contact before hospital discharge (t3), and postoperative outpatient follow-up contact after 30 days (t4).

results56% of patients had an episode of mild or moderate anxiety and 5% had an episode of severe anxiety and/or depression. Subjectively perceived anxiety and depression were highest at t1, followed by t3. 30% of patients had elevated anxiety and depression scores at t1. Regression analyses showed that high subjectively perceived mental distress at t1 was associated with higher anxiety scores at t3 and t4. Women, and younger women in particular, were significantly more likely to experience stress than men. Higher levels of subjectively perceived stress at t1 were associated with higher levels of anxiety at t3 and t4. Sociodemographic factors were not relevant predictors of anxiety.

conclusionAnxiety and depression appear to be a persistent problem during the perioperative course in patients with gastrointestinal tumors. Identifying patients at risk for clinically relevant anxiety and depression remains a particular challenge. The results confirm the relevance of repeated screening for mental distress.

Indexed as

AnxietyGastrointestinal NeoplasmsPerioperative PeriodAdultAgedAged, 80 and overDepressionFemaleGermanyHumansMaleMiddle AgedPatient Health QuestionnaireAnxietyCancerDepressionDistressGastrointestinal tumorSurgery

Identifiers

PMID37060473
PMCPMC10374702
OpenAlexW4365810930

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.