Evidence map›Paper›PMID 37060378›Full record

ArticleInsights into imaging2023

Intra- and peri-tumoral MRI radiomics features for preoperative lymph node metastasis prediction in early-stage cervical cancer.

Zhenhua Zhang, Xiaojie Wan, Xiyao Lei, Yibo Wu, Ji Zhang, Yao Ai, Bing Yu, Xinmiao Liu, Juebin Jin, Congying Xie and 1 more

Open access · goldAbstract read
In one paragraph

Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhenhua Zhang *Department of Radiology, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaojie Wan *Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiyao LeiDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yibo WuDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ji ZhangDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yao AiDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Bing YuDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xinmiao LiuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Juebin JinDepartment of Medical Engineering, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Congying XieDepartment of Radiation and Medical Oncology, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wzxiecongying@163.com.
Xiance JinDepartment of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. jinxc1979@hotmail.com.ORCID http://orcid.org/0000-0002-4117-5953
Wenzhou Medical University · CNWomen's Hospital, School of Medicine, Zhejiang University · CN

Funding

Major Project of Wenzhou Science and Technology Bureau ZY2020011Major Project of Wenzhou Science and Technology Bureau ZY2022016The key project jointly built by the Provinces and Ministry of Zhejiang Health Commission 2021438235The key R & D project of the Department of Science and Technology of Zhejiang Province 2020C03028
6 · The paper itself

Abstract

backgroundNoninvasive and accurate prediction of lymph node metastasis (LNM) is very important for patients with early-stage cervical cancer (ECC). Our study aimed to investigate the accuracy and sensitivity of radiomics models with features extracted from both intra- and peritumoral regions in magnetic resonance imaging (MRI) with T2 weighted imaging (T2WI) and diffusion weighted imaging (DWI) for predicting LNM.

methodsA total of 247 ECC patients with confirmed lymph node status were enrolled retrospectively and randomly divided into training (n = 172) and testing sets (n = 75). Radiomics features were extracted from both intra- and peritumoral regions with different expansion dimensions (3, 5, and 7 mm) in T2WI and DWI. Radiomics signature and combined radiomics models were constructed with selected features. A nomogram was also constructed by combining radiomics model with clinical factors for predicting LNM.

resultsThe area under curves (AUCs) of radiomics signature with features from tumors in T2WI and DWI were 0.841 vs. 0.791 and 0.820 vs. 0.771 in the training and testing sets, respectively. Combining radiomics features from tumors in the T2WI, DWI and peritumoral 3 mm expansion in T2WI achieved the best performance with an AUC of 0.868 and 0.846 in the training and testing sets, respectively. A nomogram combining age and maximum tumor diameter (MTD) with radiomics signature achieved a C-index of 0.884 in the prediction of LNM for ECC.

conclusionsRadiomics features extracted from both intra- and peritumoral regions in T2WI and DWI are feasible and promising for the preoperative prediction of LNM for patients with ECC.

Indexed as

Early-stage cervical cancerLymph nodes metastasisMagnetic resonance imagingPeritumoral regionRadiomics

Identifiers

PMID37060378
PMCPMC10105820
OpenAlexW4365811178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.