Evidence map›Paper›PMID 37060052›Full record

ArticleBMC microbiology2023

Differences in gut microbiota and its metabolic function among different fasting plasma glucose groups in Mongolian population of China.

Yanchao Liu, Mingxiao Wang, Wuyuntana Li, Yumin Gao, Hailing Li, Ning Cao, Wenli Hao, Lingyan Zhao

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In one paragraph

Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yanchao LiuDepartment of Epidemiology, School of Public Health, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Mingxiao WangCspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang, Hebei Province, 050035, China.
Wuyuntana LiLaboratory for Molecular Epidemiology in Chronic Diseases, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Yumin GaoDepartment of Epidemiology, School of Public Health, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Hailing LiDepartment of Epidemiology, School of Public Health, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Ning CaoDepartment of Epidemiology, School of Public Health, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Wenli HaoLaboratory for Molecular Epidemiology in Chronic Diseases, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China.
Lingyan ZhaoDepartment of Epidemiology, School of Public Health, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, 010110, China. lingyan_zhao@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany studies reported the association between gut microbiota and type 2 diabetes mellitus (T2D), but it is still unclear which bacterial genus plays a key role and how the metabolic function of gut microbiota changes in the occurrence and development of T2D. Besides, there is a high diabetic prevalence in Mongolian population, which may be partly affected by their high calorie diet. This study identified the main bacterial genus influencing T2D in Mongolian population, and analyzed the changes of metabolic function of gut microbiome. The association between dietary factors and the relative abundance of main bacterial genus and its metabolic function was also studied.

methodsDietary surveys and gut microbiota test were performed on 24 Mongolian volunteers that were divided into T2D (6 cases), PRET2D (6 cases) and Control group (12 cases) according to fasting plasma glucose (FPG) values. The relative abundance and metabolic function of gut microbiome from their fecal samples were measured by metagenomic analysis. Statistic method was used to evaluate the association between dietary factors and the relative abundance of the main bacterial genus or its metabolic function.

resultsThis study found that the Clostridium genus may be one of the key bacterial genera affecting the process of T2D. First, the relative abundance of Clostridium genus was significantly different among the three groups. Second, there was a higher relative abundance of metabolic enzymes of gut bacteria in PRET2D and T2D group than that in Control group. Third, a strong correlation between Clostridium genus and many metabolic enzymes was uncovered, many of which may be produced by the Clostridium. Last, carotene intake daily was negatively correlated with the Clostridium but positively correlated with tagaturonate reductase catalyzing interconversions of pentose and glucuronate.

conclusionsThe gut Clostridium genus may play an important role in the development of T2D and it could be a potential biomarker for T2D in Mongolian population. Meanwhile, the metabolic function of gut bacteria has changed during the early stage of T2D and the changes in carbohydrate, amino acid, lipid or energy metabolism of Clostridium genus may play a critical role. In addition, the carotene intake may affect reproduction and metabolic function of Clostridium genus.

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeBacteriaBlood GlucoseDietFastingHumansBlood GlucoseCarotene intakeGut microbiotaMetabolic functionMongolian populationType 2 diabetes mellitus

Identifiers

PMID37060052
PMCPMC10105465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.