ArticleACS nano2023
Light-Triggered Mechanical Disruption of Extracellular Barriers by Swarms of Enzyme-Powered Nanomotors for Enhanced Delivery.
Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Photothermally Induced Vapor Nanobubbles Enable Disruption and Antibiotic-Improved Responsiveness in Uropathogenic Biofilms.AAPS PharmSciTech · 2026Article
- Synergistic magneto-enzymatic propulsion enables multimodal nanomotor swarms.Nature communications · 2026Article
- Nanomotor-Assisted Intravesical Chemotherapy for Bladder Tumor Reduction and Suppression of Early Tumor Regrowth.Nano letters · 2026Article
- Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice.Nature communications · 2025Article
- Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy.International journal of molecular sciences · 2025Review
- MOF Coating Enhances the Ion Tolerance of Micromotors.Angewandte Chemie (International ed. in English) · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Dual-source powered sea urchin-like nanomotors for intravesical photothermal therapy of bladder cancer.Journal of nanobiotechnology · 2025Article
- Hyaluronic Acid-Based Nanomotors: Crossing Mucosal Barriers to Tackle Antimicrobial Resistance.ACS applied materials & interfaces · 2025Article
- Review
- Urease-powered micro/nanomotors: Current progress and challenges.Journal of pharmaceutical analysis · 2025Review
- Anisotropic Micro/Nanotopography Regulating Mitochondrial Dynamics in Cardiomyocytes.Research (Washington, D.C.) · 2025Article
- Nanoparticles Fueled by Enzyme for the Treatment of Hyperlipidemic Acute Pancreatitis.ACS biomaterials science & engineering · 2024Article
- Collective buoyancy-driven dynamics in swarming enzymatic nanomotors.Nature communications · 2024Article
- Swarms of Enzymatic Nanobots for Efficient Gene Delivery.ACS applied materials & interfaces · 2024Article
- Catalase-Powered Nanobots for Overcoming the Mucus Barrier.ACS nano · 2024Article
- Review
- Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery.Pharmaceutics · 2023Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted drug delivery depends on the ability of nanocarriers to reach the target site, which requires the penetration of different biological barriers. Penetration is usually low and slow because of passive diffusion and steric hindrance. Nanomotors (NMs) have been suggested as the next generation of nanocarriers in drug delivery due to their autonomous motion and associated mixing hydrodynamics, especially when acting collectively as a swarm. Here, we explore the concept of enzyme-powered NMs designed as such that they can exert disruptive mechanical forces upon laser irradiation. The urease-powered motion and swarm behavior improve translational movement compared to passive diffusion of state-of-the-art nanocarriers, while optically triggered vapor nanobubbles can destroy biological barriers and reduce steric hindrance. We show that these motors, named Swarm 1, collectively displace through a microchannel blocked with type 1 collagen protein fibers (barrier model), accumulate onto the fibers, and disrupt them completely upon laser irradiation. We evaluate the disruption of the microenvironment induced by these NMs (Swarm 1) by quantifying the efficiency by which a second type of fluorescent NMs (Swarm 2) can move through the cleared microchannel and be taken up by HeLa cells at the other side of the channel. Experiments showed that the delivery efficiency of Swarm 2 NMs in a clean path was increased 12-fold in the presence of urea as fuel compared to when no fuel was added. When the path was blocked with the collagen fibers, delivery efficiency dropped considerably and only depicted a 10-fold enhancement after pretreatment of the collagen-filled channel with Swarm 1 NMs and laser irradiation. The synergistic effect of active motion (chemically propelled) and mechanical disruption (light-triggered nanobubbles) of a biological barrier represents a clear advantage for the improvement of therapies which currently fail due to inadequate passage of drug delivery carriers through biological barriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.