ArticleCell reports2023
A plasma membrane-associated glycolytic metabolon is functionally coupled to K
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In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Metabolomics profile in diabetes and blood glucose regulation: a systematic review.Frontiers in nutrition · 2026Pooled it
- iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations.bioRxiv : the preprint server for biology · 2026Article
- Compartmentalized Nutrient and Hormone Sensing in β-Cells: the Role of Primary Cilia.Physiology (Bethesda, Md.) · 2026Review
- Compartmentalized glycolysis powers ATP production in primary cilia and engages mitochondria via the phosphoenolpyruvate cycle.bioRxiv : the preprint server for biology · 2026Article
- Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Review
- Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production.Nature metabolism · 2026Article
- Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism.Nature communications · 2025Article
- β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies.Cells · 2025Review
- Activity-dependent citrate dynamics in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modulation of pain by ketones: a mini-review.American journal of physiology. Cell physiology · 2025Review
- Amino acid sensing by the α-cell mitochondrial phosphoenolpyruvate cycle regulates intracellular CabioRxiv : the preprint server for biology · 2025Article
- Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Review
- Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet CaeLife · 2025Article
- FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.Nature communications · 2025Article
- E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells.Genes & development · 2025Article
- Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections.Open biology · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Thuong HoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Evgeniy PotapenkoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Dawn B DavisDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address: mmerrins@medicine.wisc.edu.
University of Wisconsin–Madison · USWilliam S. Middleton Memorial Veterans Hospital · US
Funding
The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6MIntegrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4MMetabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta CellsR01DK113103 · NIDDK · YALE UNIVERSITY · PI Matthew J. Merrins · 2017 to 2026
$3.3MThe role of GLP-1 and CCK in the pancreatic islet to promote beta-cell survivalR01DK110324 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, DAWN B · 2016 to 2020
$2.0MComparative analysis of geroprotective interventions in established and novel mouse models of Alzheimer's diseaseR01AG062328 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM, MERRINS, MATTHEW J. · 2018 to 2022
$2.0MFunctional studies of the novel diabetes gene TCF19I01BX004715 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DAVIS, DAWN B · 2019 to 2023
–Metabolic regulation of islet hormone secretion in diabetesI01BX005113 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI MERRINS, MATTHEW J. · 2022 to 2025
–BLRD VA I01 BX005113NIA NIH HHS R01 AG062328NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS UC4 DK098085
Abstract
The ATP-sensitive K
Indexed as
Cell MembraneGlucagon-Secreting CellsGlycolysisInsulin-Secreting CellsAdenosine DiphosphateAnimalsElectrophysiologyGlyceraldehyde-3-Phosphate DehydrogenasesHumansKATP ChannelsLactate DehydrogenasesMicePatch-Clamp TechniquesPhosphofructokinasesAdenosine DiphosphateGlyceraldehyde-3-Phosphate DehydrogenasesKATP ChannelsLactate DehydrogenasesPhosphofructokinasesCP: Metabolismglycolysisglycolytic metaboloninside-out excised patch clampK(ATP) channelmetabolic compartmentationpyruvate kinase
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.