Trial reportJAMA network open2023
Management of Rheumatoid Arthritis With a Digital Health Application: A Multicenter, Pragmatic Randomized Clinical Trial.
Trial report in JAMA network open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03715595 (The Treat-to-target Study of Rheumatoid Arthritis Based on Smart System of Disease Management), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Treat-to-target Study of Rheumatoid Arthritis Based on Smart System of Disease Management(SSDM) : A Randomized Controlled Multicenter Trial
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effectiveness of smart healthcare for patients with rheumatoid arthritis: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Electronic patient-reported outcome measures for triaging and scheduling outpatient appointments: a systematic review and meta-analysis.Journal of the American Medical Informatics Association : JAMIA · 2025Pooled it
- Pooled it
- Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped-Wedge Cluster Randomized Pragmatic Trial.Arthritis care & research · 2026Trial
- The Analytical Framework of Clinical Trials Evaluating Clinical Outcomes of Artificial Intelligence-Based Digital Health Interventions: A Systematic Literature Review.Journal of market access & health policy · 2026Review
- Clinical investigation of a digital biomarker for joint swelling in inflammatory arthritis based on automated quantification of dorsal finger fold patterns.Scientific reports · 2026Article
- Experiences of rheumatoid arthritis patients with digital health technologies in self-management: a qualitative study.Rheumatology international · 2026Article
- From 'Me too' to 'Me better' and 'Me cooler': the recent rheumatology advances in China.EULAR rheumatology open · 2026Review
- Emerging trends in the management of difficult-to-treat rheumatoid arthritis: targeted treatments and non-pharmacological interventions.Rheumatology (Oxford, England) · 2026Review
- An Intelligent Interactive Management Platform for Rheumatoid Arthritis Care: Real-World Observational Study.JMIR medical informatics · 2026Observational
- Exploring digital health technology in rheumatology: a scoping review on benefits, challenges, and future possibilities.EULAR rheumatology open · 2026Review
- The emerging role of clinimetrics in pediatric rheumatology.Pediatric rheumatology online journal · 2026Article
- Digital Health Interventions to Support Chronic Disease Management: Systematic Scoping Review.JMIR mHealth and uHealth · 2026Article
- Internet healthcare in Chinese public hospitals: Towards high-quality development (1986-present).AIMS public health · 2026Review
- Predictors of adherence to a digital health application in patients with inflammatory arthritis: retrospective analysis.Rheumatology international · 2025Article
- Transforming Rheumatoid Arthritis Care: A Scoping Review of the Role of Digital Health.Cureus · 2025Review
- European advances in digital rheumatology: explainable insights and personalized digital health tools for psoriatic arthritis.EClinicalMedicine · 2025Review
- Professional-Facing Digital Health Technology for the Care of Patients With Chronic Pain: Scoping Review.Journal of medical Internet research · 2025Article
- Predictors of Boolean2.0 remission in rheumatoid arthritis identified using smart disease management system data.Scientific reports · 2025Observational
- Digital Health for Equitable Rheumatic Care: Integrating Real-World Experiences to Guide Policy Pathways.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceDigital health applications have been shown to be effective in the management of chronic diseases with simple treatment targets. The potential clinical value of digital health applications in rheumatoid arthritis (RA) has not been well studied.
objectiveTo investigate whether assessing patient-reported outcomes using digital health applications could result in disease control for patients with RA. DESIGN, SETTING, AND
participantsThis is a multicenter, open-label randomized clinical trial in 22 tertiary hospitals across China. Eligible participants were adult patients with RA. Participants were enrolled from November 1, 2018, to May 28, 2019, with a 12-month follow-up. The statisticians and rheumatologists who assessed disease activity were blinded. Investigators and participants were not blind to group assignment. Analysis was conducted from October 2020 to May 2022.
interventionsParticipants were randomly assigned at a 1:1 ratio (block size of 4) to a smart system of disease management group (SSDM) or a conventional care control group. Upon the completion of the 6-month parallel comparison, patients in the conventional care control group were instructed to use the SSDM application for an extension of 6 months. MAIN OUTCOMES AND MEASURES: The primary outcome was the rate of patients with disease activity score in 28 joints using the C-reactive protein (DAS28-CRP) of 3.2 or less at month 6.
resultsOf 3374 participants screened, 2204 were randomized, and 2197 patients with RA (mean [SD] age, 50.5 [12.4] years; 1812 [82.5%] female) were enrolled. The study included 1099 participants in the SSDM group and 1098 participants in the control group. At month 6, the rate of patients with DAS28-CRP of 3.2 or less was 71.0% (780 of 1099 patients) in the SSDM group vs 64.5% (708 of 1098 patients) in the control group (difference between groups, 6.6%; 95% CI, 2.7% to 10.4%; P = .001). At month 12, the rate of patients with DAS28-CRP of 3.2 or less in the control group increased to a level (77.7%) that was comparable with that (78,2%) in the SSDM group (difference between groups, -0.2%; 95% CI, -3.9% to 3.4%; P = .90). CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of RA, the use of a digital health application with patient-reported outcomes was associated with an increase in disease control rate.
trial registrationClinicalTrials.gov Identifier: NCT03715595.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.