Evidence map›Paper›PMID 37058265›Full record

ArticleObesity surgery2023

Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery.

Salva R Yurista, Shi Chen, Robert A Eder, Thomas Garrett, W Scott Butsch, Ali Aminian, W H Wilson Tang, Christian T Farrar, Denise Gee, E Dale Abel and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Salva R YuristaCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.ORCID 0000-0001-9126-739X
Shi ChenCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Robert A EderCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Thomas GarrettCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
W Scott ButschBariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Ali AminianBariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Christian T FarrarAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Denise GeeMGH Weight Center, Department of Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
E Dale AbelDepartment of Medicine, David Geffen School of Medicine and UCLA Health, Los Angeles, CA, 90095, USA.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Christopher T NguyenCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA. nguyenc6@ccf.org.ORCID 0000-0003-1475-2329
Cleveland Clinic · USHarvard University · USMassachusetts General Hospital · USUCLA Health · US

Funding

Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and SensitivityR01EB031008 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTIAN T FARRAR · 2021 to 2026
$4.0M
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Stress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8M
A CEST-MRI Reporter Gene for Image Guided Oncolytic VirotherapyR01CA203873 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FARRAR, CHRISTIAN T · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA203873NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010NIBIB NIH HHS R01 EB031008
6 · The paper itself

Abstract

backgroundObesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective study examined the impact of bariatric surgery on cardiac function and metabolism.

methodsSubjects with obesity underwent cardiac magnetic resonance imaging (CMR) at Massachusetts General Hospital before and after bariatric surgery between 2019 and 2021. The imaging protocol included Cine for global cardiac function assessment and creatine chemical exchange saturation transfer (CEST) CMR for myocardial creatine mapping.

resultsThirteen subjects were enrolled, and 6 subjects [mean BMI 40.5 ± 2.6] had completed the second CMR (i.e. post-surgery), with a median follow-up of 10 months. The median age was 46.5 years, 67% were female, and 16.67% had diabetes. Bariatric surgery led to significant weight loss, with achieved mean BMI of 31.0 ± 2.0. Additionally, bariatric surgery resulted in significant reduction in left ventricular (LV) mass, LV mass index, and epicardial adipose tissue (EAT) volume. This was accompanied by slight improvement in LV ejection fraction compared to baseline. Following bariatric surgery, there was a significant increase in creatine CEST contrast. Subjects with obesity had significantly lower CEST contrast compared to subjects with normal BMI (n = 10), but this contrast was normalized after the surgery, and statistically similar to non-obese cohort, indicating an improvement in myocardial energetics.

conclusionsCEST-CMR has the ability to identify and characterize myocardial metabolism in vivo non-invasively. These results demonstrate that in addition to reducing BMI, bariatric surgery may favorably affect cardiac function and metabolism.

Indexed as

Bariatric SurgeryObesity, MorbidCreatineFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedObesityProspective StudiesVentricular Function, LeftCreatineBariatric surgeryCardiac functionChemical saturation exchange transferMagnetic resonance imagingMyocardial energeticsObesity

Identifiers

PMID37058265
PMCPMC11100502
OpenAlexW4365479517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.