Evidence map›Paper›PMID 37058254›Full record

SynthesisCurrent pain and headache reports2023

Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral Neuropathy.

Ryan S D'Souza, Gabriel A Martinez Alvarez, Marissa Dombovy-Johnson, Jennifer Eller, Alaa Abd-Elsayed

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current pain and headache reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06834685 (Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06834685 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy: a Randomized, Non-comparative, Placebo-controlled, Single-blinded, Phase II Clinical Trial in Cancer Patients

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2025 to 2028Enrolled70ConditionsCancer Survivors, Peripheral Neuropathic PainArmsPhotobiomodulation sessions
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. BeyondFrontiers in pain research (Lausanne, Switzerland) · 2025
    Pooled it
  3. Efficacy of cryotherapy in the prevention of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Interventional Therapies to Treat Cancer Associated Pain.Current treatment options in oncology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ryan S D'SouzaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4601-9837
Gabriel A Martinez AlvarezDepartment of Physical Medicine and Rehabilitation, Mayo Clinic Hospital, Rochester, MN, USA.
Marissa Dombovy-JohnsonDepartment of Physical Medicine and Rehabilitation, Mayo Clinic Hospital, Rochester, MN, USA.
Jennifer EllerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.
Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA. abdelsayed@wisc.edu.
Mayo Clinic Hospital · USMayo Clinic in Arizona · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and often painful condition that occurs after administration of chemotherapeutic agents. The primary objective of this systematic review was to appraise the literature on conservative, pharmacological, and interventional treatment options for CIPN pain. RECENT

findingsThere is level I evidence supporting modest to moderate improvement in CIPN pain from duloxetine treatment, as well as short-term modest improvement from physical therapy and acupuncture. Although opioid and cannabis administration may provide short-term modest improvement, administration is commonly limited by side effects. Generally, most studies reported no clinical benefit from yoga, topical neuropathic agents, gabapentinoids, and tricyclic antidepressants. Evidence is currently equivocal for scrambler therapy and transcutaneous electrical nerve stimulation. Finally, evidence on neuromodulation options is limited to mostly case reports/series and one observational study highlighting moderate improvement with auricular nerve stimulation. This systematic review provides an overview of conservative, pharmacologic, and interventional treatment modalities for CIPN pain. Furthermore, it provides a level of evidence and degree of recommendation based on the United States Preventive Services Task Force (USPSTF) criteria for each specific treatment modality.

Indexed as

Antineoplastic AgentsNeoplasmsNeuralgiaTranscutaneous Electric Nerve StimulationHumansObservational Studies as TopicPain ManagementAntineoplastic AgentsCancerChemotherapyChronic painNeuromodulationPeripheral neuropathySystematic review

Identifiers

PMID37058254
OpenAlexW4365479660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.