Evidence map›Paper›PMID 37058164›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Predictive value of health-related quality of life on radiotherapy-related toxicities in patients with head and neck cancer.

Oumar Billa, Franck Bonnetain, Jérôme Chamois, Angeline Ligey, Valérie Ganansia, Sophie Renard, Sophie Maillard, Magali Quivrin, Noémie Vulquin, Pierre Truntzer and 3 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Comment on: Predictive value of health-related quality of life on radiotherapy-related toxicities in patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Oumar BillaEpidemiology and Quality of Life Unit, Georges-François Leclerc Cancer Centre-UNICANCER, 21000, Dijon, France. obilla@cgfl.fr.ORCID http://orcid.org/0000-0002-5661-9406
Franck BonnetainMethodology and Quality of Life in Oncology Unit, Inserm UMR 1098, University Hospital of Besancon, Besancon, France.
Jérôme ChamoisCentre Hospitalier Saint Gregoire, 35760, Saint-Grégoire, France.
Angeline LigeyCentre Hospitalier Fleriat, 01012, Bourg-en-Bresse, France.
Valérie GanansiaPaul Strauss Cancer Centre-Unicancer, 67000, Strasbourg, France.
Sophie RenardInstitut de Cancérologie de Lorraine, 54519, Vandœuvre-lès-Nancy, France.
Sophie MaillardCentre Bourgogne, 59000, Lille, France.
Magali QuivrinRadiotherapy Department, Georges-François Leclerc Cancer Centre-UNICANCER, 1 Rue Professeur Marion, 21000, Dijon, France.
Noémie VulquinRadiotherapy Department, Georges-François Leclerc Cancer Centre-UNICANCER, 1 Rue Professeur Marion, 21000, Dijon, France.
Pierre TruntzerPaul Strauss Cancer Centre-Unicancer, 67000, Strasbourg, France.
Georges NoelPaul Strauss Cancer Centre-Unicancer, 67000, Strasbourg, France.
Philippe MaingonRadiotherapy Department, Georges-François Leclerc Cancer Centre-UNICANCER, 1 Rue Professeur Marion, 21000, Dijon, France.
Tienhan Sandrine Dabakuyo-YonliEpidemiology and Quality of Life Unit, Georges-François Leclerc Cancer Centre-UNICANCER, 21000, Dijon, France.
Inserm · FRCentre Georges François Leclerc · FRUniCancer Group · FRCentre Hospitalier privé Saint Grégoire · FRInstitut de Cancérologie de Lorraine · FRInstitut de Cancérologie Strasbourg · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLittle is known about whether baseline health-related quality of life (HRQoL) scores also could predict occurrence radiotherapy-related toxicities, which we aim to assess in this study.

methodsThis study analyzed data from 200 patients enrolled in randomized study investigating the utility of HRQoL. HRQOL was assessed at baseline and during follow up using QLQ-C30 questionnaire and major toxicity was considered as adverse event ≥ 3 according to NCI-CTCAE classification. Cox regressions adjusting for clinical and sociodemographic data were used to assess prognostic significance of HRQOL scores.

resultsIn multivariable analyses adjusted on clinical and sociodemographic data, every 10-point improvement in physical (HR = 0.74), role (HR = 0.87) and social (HR = 0.88) functioning was associated with 24%, 13% and 12% lower hazard of occurrence of major toxicity respectively while every 10 point-increase in dyspnea (HR = and loss appetite was associated with 15% and 16% increased hazard of major toxicity.

conclusionCertain baseline HRQoL scores were found to be significantly associated with the occurrence of major toxicity.

Indexed as

Head and Neck NeoplasmsQuality of LifeHumansPrognosisSurveys and QuestionnairesHead and neck cancerHealth related quality of lifePredictive factors

Identifiers

PMID37058164
OpenAlexW4365483313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.