Evidence map›Paper›PMID 37057991›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Electronic cigarettes prolong ventricular repolarization in people who smoke tobacco cigarettes: implications for harm reduction.

Isabelle Ruedisueli, Karishma Lakhani, Randy Nguyen, Jeffrey Gornbein, Holly R Middlekauff

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Review
  5. Article
  6. Insights into the effect of pre- and postnatal nicotine exposure on cardiovascular development and function.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  7. Article
  8. Article
  9. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  10. Glycation in the cardiomyocyte.Vitamins and hormones · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Isabelle RuedisueliDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, United States.
Karishma LakhaniDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, United States.
Randy NguyenDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, United States.
Jeffrey GornbeinDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, United States.
Holly R MiddlekauffDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, United States.ORCID 0000-0001-7848-8585
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

Electronic cigarettes are often used for smoking cessation as a harm reduction strategy, but studies comparing risks of electronic cigarettes (ECs) and tobacco cigarettes (TCs) are scarce. Ventricular repolarization in people who smoke TCs is abnormal. Baseline repolarization was compared among nonusers (people who do not use TCs or ECs) and people who use ECs or TCs. The acute effects of ECs and TCs on metrics of ventricular repolarization were then compared in people who chronically smoke. A total of 110 participants (59 female), including 35 people (21 females) in the TC cohort, 34 people (17 females) in the EC cohort, and 41 people (21 females) in the nonuser cohort, were included. None of the primary outcomes, T

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsFemaleHarm ReductionHumansMaleNicotineSmokingNicotineelectronic cigarettesnicotinetobacco cigarettesTpeak-Tendventricular repolarization

Identifiers

PMID37057991
PMCPMC10191123
OpenAlexW4365483268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.