Evidence map›Paper›PMID 37057896›Full record

ArticleeLife2023

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates.

Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hiroshi YamaguchiDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8722-129X
Motohiro MorikawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8803-9377
Masahide KikkawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7656-8194
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in vertebrates. Here, we analyzed the functions of Calaxin/Efcab1 and Armc4, the two of five components of vertebrate OAD-DC (docking complex), using zebrafish spermatozoa and cryo-electron tomography. Mutation of

Indexed as

CiliaCytoskeletal ProteinsDyneinsMicrotubulesZebrafishAnimalsArmadillo Domain ProteinsAxonemeCalcium-Binding ProteinsCryoelectron MicroscopyMaleMicroscopy, FluorescenceModels, MolecularMutationProtein StabilitySpermatozoaArmadillo Domain ProteinsCalcium-Binding ProteinsCytoskeletal ProteinsDyneinsEfcab1 protein, zebrafishZebrafish Proteinsaxonemecalaxincell biologyciliacryo-ETdyneinmolecular biophysicsspermstructural biologyzebrafish

Identifiers

PMID37057896
PMCPMC10139691
OpenAlexW4365478924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.