Evidence map›Paper›PMID 37057753›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Association of primary lifetime occupational cognitive complexity and cognitive decline in a diverse cohort: Results from the KHANDLE study.

Yenee Soh, Chloe W Eng, Elizabeth Rose Mayeda, Rachel A Whitmer, Catherine Lee, Rachel L Peterson, Dan M Mungas, M Maria Glymour, Paola Gilsanz

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Occupational autonomy and cognitive function: the moderating role of educational attainment.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Occupational position and complexity in relation to Black-White cognitive disparities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Lifespan exposures to rural-urban conditions and later-life cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Physical and mental demands of work associated with dementia risk in later life.The journal of prevention of Alzheimer's disease · 2025
    Article
  9. Review
  10. Article
  11. 2024 Alzheimer's disease facts and figures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yenee SohDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Chloe W EngDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
Rachel A WhitmerDepartment of Neurology, School of Medicine, University of California, Davis, Davis, California, USA.
Catherine LeeDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Rachel L PetersonSchool of Public and Community Health Sciences, University of Montana, Missoula, Montana, USA.
Dan M MungasDepartment of Neurology, School of Medicine, University of California, Davis, Davis, California, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related DementiasR00AG073457 · NIA · UNIVERSITY OF MONTANA · PI PETERSON, RACHEL LYNNE · 2022 to 2024
$724k
NIA NIH HHS P30 AG072972NIA NIH HHS R00 AG073457NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG066132
6 · The paper itself

Abstract

introductionHigher occupational complexity has been linked to favorable cognitive outcomes, but rarely examined in racially and ethnically diverse populations.

methodsIn a diverse cohort (n = 1536), linear mixed-effects models estimated associations between main lifetime occupational complexity and domain-specific cognitive decline (z-standardized). Occupational complexity with data, people, and things were classified using the Dictionary of Occupational Titles.

resultsFor occupational complexity with data, highest tertile (vs. lowest) was associated with higher baseline executive function (β = 0.11; 95% confidence interval [CI] 0.00-0.22) and slower annual rate of decline (β = 0.03; 95% CI 0.01-0.06), and higher baseline semantic memory (β = 0.14; 95% CI 0.04-0.25). Highest tertile of occupational complexity with people was associated with higher baseline executive function (β = 0.29; 95% CI 0.18-0.40), verbal episodic memory (β = 0.12; 95% CI 0.00-0.24), and semantic memory (β = 0.23; 95% CI 0.12-0.34). DISCUSSION: In a diverse cohort, higher occupational complexity is associated with better cognition. Findings should be verified in larger cohorts. HIGHLIGHT: Few studies have examined associations of occupational complexity with cognition in diverse populations. Racial and ethnic minorities are disproportionately exposed to lower occupational complexity. Occupational complexity with data and people are associated with better cognition.

Indexed as

Cognitive DysfunctionCognitionExecutive FunctionHumansMemorycognitive declinecognitive functioningcognitive reservelongitudinal cohort studyoccupational complexityrisk factorswork environment

Identifiers

PMID37057753
PMCPMC10517075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.