Evidence map›Paper›PMID 37057719›Full record

ArticleMolecular oncology2023

Prognostic and predictive impact of gene expression in node-positive early breast cancer patients receiving dose-dense versus standard-dose adjuvant chemotherapy.

Mattea Reinisch, Simona Bruzas, Oleg Gluz, Beyhan Ataseven, Peter Schmid, Javier Cortés, Jens-Uwe Blohmer, Satyendra Shenoy, Mark H Dyson, Christine Dittmer-Grabowski and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Mattea ReinischBreast Unit, Kliniken Essen-Mitte, Germany.ORCID 0000-0002-1381-8595
Simona BruzasBreast Unit, Kliniken Essen-Mitte, Germany.
Oleg GluzBethesda Hospital, Breast Center Niederrhein, Mönchengladbach, Germany.
Beyhan AtasevenDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Germany.
Peter SchmidCentre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, UK.
Javier CortésInternational Breast Cancer Centre (IBCC), Quiron Group, Barcelona, Spain.
Jens-Uwe BlohmerDepartment of Gynecology with Breast Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
Satyendra ShenoyBreast Unit, Kliniken Essen-Mitte, Germany.
Mark H DysonBreast Unit, Kliniken Essen-Mitte, Germany.
Christine Dittmer-GrabowskiBreast Unit, Kliniken Essen-Mitte, Germany.
Ouafaa ChiariBreast Unit, Kliniken Essen-Mitte, Germany.
Hakima HarrachBreast Unit, Kliniken Essen-Mitte, Germany.
Daniel GebauerInstitute for Pathology Viersen, Germany.
Alexander TrautDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Germany.
Sherko KuemmelBreast Unit, Kliniken Essen-Mitte, Germany.
Kliniken Essen-Mitte · DEHumboldt-Universität zu Berlin · DEInternational Breast Cancer Study Group · CHLMU Klinikum · DELVR-Klinik für Orthopädie Viersen · DEQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The utility of multigene expression assays in advanced (≥ 4 positive lymph nodes) early breast cancer (EBC) is limited. We conducted exploratory transcriptomic analysis of 758 genes (Breast Cancer 360 panel, nCounter

Indexed as

Breast NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorChemotherapy, AdjuvantDisease-Free SurvivalErb-b2 Receptor Tyrosine KinasesFemaleGene ExpressionHumansPrognosisBiomarkers, TumorErb-b2 Receptor Tyrosine Kinasesadjuvant chemotherapydose-dense chemotherapyearly breast cancergene signaturelymph node-positive

Identifiers

PMID37057719
PMCPMC10257423
OpenAlexW4365483289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.