Evidence map›Paper›PMID 37057180›Full record

ArticleFrontiers in physiology2023

Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery.

Lubomir T Lubomirov, Mechthild M Schroeter, Veronika Hasse, Marina Frohn, Doris Metzler, Maria Bust, Galyna Pryymachuk, Jürgen Hescheler, Olaf Grisk, Joseph M Chalovich and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Lubomir T LubomirovCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Mechthild M SchroeterCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Veronika HasseCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Marina FrohnCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Doris MetzlerCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Maria BustCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Galyna PryymachukInstitute of Anatomy, University of Cologne, Cologne, Germany.
Jürgen HeschelerCenter of Physiology, Institute of Neurophysiology, University of Cologne, Cologne, Germany.
Olaf GriskInstitute of Physiology, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Joseph M ChalovichDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC, United States.
Neil R SmythBiological Sciences, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.
Gabriele PfitzerCenter of Physiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.
Symeon PapadopoulosCenter of Physiology, Institute of Neurophysiology, University of Cologne, Cologne, Germany.
University of Cologne · DEEast Carolina University · USMedizinische Hochschule Brandenburg Theodor Fontane · DESouthampton General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stretch-induced vascular tone is an important element of autoregulatory adaptation of cerebral vasculature to maintain cerebral flow constant despite changes in perfusion pressure. Little is known as to the regulation of tone in senescent basilar arteries. We tested the hypothesis, that thin filament mechanisms in addition to smooth muscle myosin-II regulatory-light-chain-(MLC

Indexed as

basilar arterycaldesmonnon-muscle myosinsenescencestretch-induced tone

Identifiers

PMID37057180
PMCPMC10088910
OpenAlexW4361216974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.