Evidence map›Paper›PMID 37057088›Full record

ArticleERJ open research2023

Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

Aparna Balasubramanian, Janet T Holbrook, Brendan J Canning, Loretta G Que, Mario Castro, Barry J Make, Linda Rogers, Michael F Busk, Alexis Rea, Ashley A McCook-Veal and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Aparna BalasubramanianThe Johns Hopkins University, School of Medicine, Pulmonary and Critical Care Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-1854-6672
Janet T HolbrookThe Johns Hopkins University, Bloomberg School of Public Health, Epidemiology, Baltimore, MD, USA.
Brendan J CanningThe Johns Hopkins University, School of Medicine, Pulmonary and Critical Care Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-4197-5560
Loretta G QueDuke University School of Medicine, Pulmonary, Allergy, and Critical Care Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0001-9188-9244
Mario CastroKansas University Medical Center, Pulmonary, Critical Care and Sleep Medicine, Kansas City, KA, USA.
Barry J MakeNational Jewish Health, Division of Pulmonary, Critical Care and Sleep Medicine, Denver, CO, USA.ORCID https://orcid.org/0000-0003-4349-8745
Linda RogersIcahn School of Medicine at Mount Sinai, Pulmonary, Critical Care and Sleep Medicine, New York, NY, USA.
Michael F BuskSt Vincent Health, Wellness and Preventive Care Institute, Indianapolis, IN, USA.
Alexis ReaThe Johns Hopkins University, Bloomberg School of Public Health, Epidemiology, Baltimore, MD, USA.
Ashley A McCook-VealThe Johns Hopkins University, Bloomberg School of Public Health, Epidemiology, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-5368-4977
Jiaxian HeThe Johns Hopkins University, Bloomberg School of Public Health, Epidemiology, Baltimore, MD, USA.
Meredith C McCormackThe Johns Hopkins University, School of Medicine, Pulmonary and Critical Care Medicine, Baltimore, MD, USA.
Robert A WiseThe Johns Hopkins University, School of Medicine, Pulmonary and Critical Care Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8353-2349
Johns Hopkins University · USDuke University · USIcahn School of Medicine at Mount Sinai · USNational Jewish Health · USSt Vincent Hospital · USUniversity Medical Center · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Pulmonary Vascular Disease as a Contributor to Respiratory Morbidity in Chronic Obstructive Pulmonary DiseaseK23HL153778 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Aparna Balasubramanian · 2022 to 2026
$991k
Pilot Study of Zinc Acetate for Chronic CoughR34HL132369 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CANNING, BRENDAN J, HOLBROOK, JANET T. · 2016 to 2018
$735k
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K23 HL153778NHLBI NIH HHS R34 HL132369
6 · The paper itself

Abstract

Background: Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and efficacy of zinc acetate in the management of chronic refractory cough. Study design and methods: This was a randomised, placebo-controlled, parallel-design pilot trial of individuals with chronic refractory cough. The effects of 6 weeks of zinc acetate Results: 34 participants, 17 in each group, were enrolled and randomised. Participants were primarily white females with moderate-severe cough. Participants assigned to zinc acetate had a significant increase in serum zinc levels after 6 weeks, while those assigned to placebo did not. Both groups showed improvement in CQLQ, LCQ, C-VAS and GACC scores, but the treatment effects of zinc acetate Interpretation: We observed no benefit of zinc therapy over placebo on cough symptoms or quality of life and conclude that larger trials of zinc for chronic cough are not warranted.

Identifiers

PMID37057088
PMCPMC10086688
OpenAlexW4323667302

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.