Evidence map›Paper›PMID 37056929›Full record

ArticleInternational journal of biological sciences2023

LTF Induces Radioresistance by Promoting Autophagy and Forms an AMPK/SP2/NEAT1/miR-214-5p Feedback Loop in Lung Squamous Cell Carcinoma.

Junmiao Wen, Wang Zheng, Liang Zeng, Boyan Wang, Donglai Chen, Yongbing Chen, Xueguan Lu, Chunlin Shao, Jiayan Chen, Min Fan

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  12. DAPK3 is Essential for DBP-Induced Autophagy of Mouse Leydig Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Article
  15. LTF regulates glioblastoma progression and temozolomide resistance via the NF-κB signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  16. CRISPR/Cas13 sgRNA-Mediated RNA-RNA Interaction Mapping in Live Cells with APOBEC RNA Editing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Junmiao WenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Wang ZhengInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Liang ZengInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Boyan WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Donglai ChenDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yongbing ChenDepartment of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Xueguan LuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Chunlin ShaoInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Jiayan ChenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Min FanDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Fudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNFudan University · CNSecond Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is the most predominant treatment strategy for lung squamous cell carcinoma (LUSC) patients, but radioresistance is the major obstacle to therapy effectiveness. The mechanisms and regulators of LUSC radioresistance remain unclear. Here, lactotransferrin (LTF) is found to be significantly upregulated in radioresistant LUSC cell lines (H226R and H1703R) and clinical samples and promotes radioresistance of LUSC both

Indexed as

Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung NeoplasmsMicroRNAsAMP-Activated Protein KinasesAutophagyFeedbackHumansLactoferrinLungAMP-Activated Protein KinasesLactoferrinLTF protein, humanMicroRNAsMIRN214 microRNA, humanautophagyLTFlung cancerradioresistance

Identifiers

PMID37056929
PMCPMC10086751
OpenAlexW4324009505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.