ArticleNeuropsychiatric disease and treatment2023
Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms.
Article in Neuropsychiatric disease and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- The relationship between homocysteine and post-stroke depression in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- Correlation of anxiety/depression status with stress-related markers and cancer-related fatigue in patients with colon cancer.World journal of psychiatry · 2026Article
- Preliminary Exploration on the Effects of a Novel Antidepressant Formula Food in a Mouse Model.Foods (Basel, Switzerland) · 2025Article
- Association between post-traumatic stress disorder levels and serum inflammatory factors in patients undergoing digit replantation.Frontiers in neuroscience · 2025Article
- Analysis of risk factors for depression and anxiety in women with polycystic ovary syndrome.Frontiers in global women's health · 2025Article
- Fermentative production of vitamin BFood science & nutrition · 2024Review
- Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization.Nutrients · 2024Article
- Cq values as an indicator for COVID-19 outcomes: A study of the correlation between laboratory parameters.Immunity, inflammation and disease · 2024Article
- Gut microbiota and inflammatory factor characteristics in major depressive disorder patients with anorexia.BMC psychiatry · 2024Article
- Vitamin B12 and homocysteine in patients with major depressive disorder.Journal of family medicine and primary care · 2024Article
- Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores.PloS one · 2024Article
- Homocysteine levels in first-episode patients with psychiatric disorders.Frontiers in psychiatry · 2024Article
- Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption.International journal of molecular sciences · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine (tHcy), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels, to analyze the relationship between these parameters and the severity of anxiety or depressive symptoms, and to explore the possible factors associated with abnormal levels of these parameters in adolescents with anxiety or depressive symptoms. Methods: Adolescent (aged 12-18 years) outpatients with anxiety or depressive symptoms were recruited. The patient health questionnaire-9 and generalized anxiety disorder scale-7 were used to measure the severity of depression and anxiety. Serum vitamin B12, folate, tHcy, IL-6, TNF-α, and CRP levels were determined. Results: 128 subjects were recruited. The prevalence of vitamin B12 and folate deficiency, tHcy, TNF-α, IL-6, and CRP elevation was 8.6%, 10.2%, 25.8%, 14.8%, 21.9%, and 10.2%, respectively, in adolescents with anxiety or depressive symptoms. Lower vitamin B12 levels were correlated with a higher risk of severe anxiety and depressive symptoms. The severity of some symptoms of anxiety or depression were weakly correlated with vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were not associated with inflammatory mediators. Vitamin B12 deficiency was associated with older age and higher tHcy levels. Folate deficiency was associated with elevated tHcy. Elevated tHcy was associated with lower vitamin B12 and folate levels. IL-6 elevation was associated with elevated CRP and TNF-α. CRP elevation was associated with older age, higher BMI, and current drinking. Conclusion: Lower vitamin B12 levels were correlated with a higher risk of severe anxiety or depressive symptoms. Weak correlations were observed between the severity of some symptoms of anxiety or depression and vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were related to each other. IL-6 elevation was associated with elevated CRP and TNF-α. CRP elevation was associated with older age, higher BMI, and current drinking.
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