ArticleAmerican journal of translational research2023
COX10-AS1-mediated miR-361-5p regulated cell invasion and migration by targeting SPRY1 in oral squamous cell carcinoma.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- MicroRNA regulation of macrophage polarization in lung cancer: Regulatory networks and therapeutic potential (Review).International journal of oncology · 2026Review
- Review
- miR-361-5p regulates acute infective endocarditis by mediating SLPI/NF-κB signaling pathway.Cytotechnology · 2025Article
- Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma.Journal of experimental & clinical cancer research : CR · 2025Article
- Potential role of lnc-METRNL-1 in the occurrence and prognosis of oral squamous cell carcinoma.3 Biotech · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOX10-AS1 belongs to the class of lncRNA and has been shown to influence carcinogenesis; however, its function and underlying mechanism in oral squamous cell carcinoma are still unclear (OSCC).
methodWestern blotting, immunohistochemistry, and RT-PCR were used to identify gene expression. Cell invasion and migration were discovered using Transwell and Scratch-Wound analyses. The interaction between lncRNA and miRNA was examined using dual-luciferase and immunofluorescence assays.
resultsWe discovered that COX10-AS1 was significantly downregulated in OSCC tissues when compared to matched noncancerous tissues, indicating a dismal prognosis for OSCC patients. By raising the expression of MMP-2/-9 and Snail and lowering the expression of E-cadherin, COX10-AS1 deletion increased OSCC cell invasion and migration. Next, three binding sites between COX10-AS1 and miR-361-5p were shown in the StarBase V2.0 database. Pearson's correlation analysis revealed a negative association between the expression of COX10-AS1 and that of miR-361-5p, and miR-361-5p transfection reduced COX10-AS1's influence on OSCC cell invasion and migration. Furthermore, COX10-AS1 favorably regulated SPRY1, a miR-361-5p target gene.
conclusionThrough the miR-361-5p/SPRY1 axis, COX10-AS1 can act as a tumor suppressor and is decreased in OSCC.
Indexed as
Identifiers
37056821PMC10086905W4365483339What OpenQuestion holds
Registered trials
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