ArticleAmerican journal of translational research2023
Correlation between serum 4-HNE and lactic acid levels and disease status in patients with severe pneumonia and its diagnostic value and prognostic evaluation.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- 4-Hydroxynonenal, a Potential Biomarker for Lung Inflammatory Diseases.International journal of molecular sciences · 2026Review
- Side effects of increased lactate concentrations in the blood in various clinical situations.American journal of translational research · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
purposeTo investigate the relationship between serum 4-Hydroxynonenal (4-HNE) and lactic acid (Lac) levels and the disease status of severe pneumonia (SP) patients, and to observe the value of serum 4-HNE and Lac in the prognosis assessment of SP patients.
methodsThe clinical data of 76 patients with SP (SP group) and 76 patients with general pneumonia (GP group) in Shanghai Ninth People's Hospital from September 2020 to June 2022 were retrospectively collected. According to the survival status of SP patients 28 d after admission, they were divided into a survival group (49 cases) and a death group (27 cases). Serum 4-HNE and Lac levels were compared between groups. Pearson was used to observe the correlation between serum 4-HNE and Lac levels and SP disease status. Receiver operating characteristic curve was used to analyze the evaluation efficacy of serum 4-HNE and Lac levels.
resultsThe levels of serum 4-HNE and Lac in the SP group were higher than in the GP group (P<0.05). Serum 4-HNE and Lac levels in SP patients were positively correlated with CURB-65 score (r=0.626; r=0.427, P<0.05). The levels of serum 4-HNE and Lac in the death group were higher than survival group (P<0.05). Area under curve (AUC) of serum 4-HNE and Lac levels in the diagnosis of SP was 0.796 and 0.799 respectively. AUC for serum 4-HNE combined with Lac levels in the diagnosis of SP was 0.871. AUC of serum 4-HNE and Lac levels in predicting the prognosis of SP was 0.768 and 0.663 respectively. AUC of serum 4-HNE combined with Lac levels in predicting the prognosis of SP was 0.837.
conclusionSerum 4-HNE and Lac levels in SP patients are significantly increased, and serum 4-HNE combined with Lac level has good application value in the early diagnosis and prognosis prediction of SP.
Indexed as
Identifiers
37056801PMC10086918W4365484798What OpenQuestion holds
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