Evidence map›Paper›PMID 37056783›Full record

ArticleFrontiers in immunology2023

Induction of antigen specific intrahepatic CD8+ T cell responses by a secreted heat shock protein based gp96-Ig-PfCA malaria vaccine.

Laura Padula, Eva Fisher, Wathsala Wijayalath, Noelle B Patterson, Jun Huang, Harini Ganeshan, Tanisha Robinson, François A Bates, Margaret A Hanson, Monica L Martin and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Laura PadulaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Eva FisherDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Wathsala WijayalathMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Noelle B PattersonMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Jun HuangMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Harini GaneshanMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Tanisha RobinsonMalaria Serology Lab, Immunology Core, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
François A BatesAnimal Medicine Branch, Veterinary Services Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Margaret A HansonNecropsy Branch, Veterinary Services Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Monica L MartinAnimal Medicine Branch, Veterinary Services Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Katelyn RivasDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Denisse GarciaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Kimberly A EdgelMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Martha SedegahMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Eileen VillasanteMalaria Department, Naval Medical Research Center (NMRC), Silver Spring, MD, United States.
Natasa StrboDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
University of Miami · USNaval Medical Research Command · USHenry M. Jackson Foundation · USWalter Reed Army Institute of Research · USParsons (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A highly efficacious and durable vaccine against malaria is an essential tool for global malaria eradication. One of the promising strategies to develop such a vaccine is to induce robust CD8+ T cell mediated immunity against malaria liver-stage parasites. Methods: Here we describe a novel malaria vaccine platform based on a secreted form of the heat shock protein, gp96-immunoglobulin, (gp96-Ig) to induce malaria antigen specific, memory CD8+ T cells. Gp96-Ig acts as an adjuvant to activate antigen presenting cells (APCs) and chaperone peptides/antigens to APCs for cross presentation to CD8+ T cells. Results: Our study shows that vaccination of mice and rhesus monkeys with HEK-293 cells transfected with gp96-Ig and two well-known Discussion: Our novel gp96-Ig malaria vaccine strategy represents a unique approach to induce liver-homing, antigen-specific CD8+ T cells critical for

Indexed as

MalariaMalaria, FalciparumMalaria VaccinesAntigens, ProtozoanCD8-Positive T-LymphocytesHeat-Shock ProteinsHEK293 CellsHumansImmunoglobulinsAntigens, ProtozoanHeat-Shock ProteinsImmunoglobulinsMalaria VaccinesGp96liver CD8+ T cells specificmalariamemoryvaccine

Identifiers

PMID37056783
PMCPMC10086177
OpenAlexW4361214128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.